Results 61 to 70 of about 196,484 (310)

Political crisis in Slovakia 2018: R. Fico resignation and new cabinet of Pellegrini [PDF]

Научно-аналитический вестник Института Европы РАН, 2018
The article shows development of the political crisis in Slovakia in February - March 2018, during which Prime Minister R. Fico was forced to resign. Subsequently new cabinet of ministers under the leadership of P. Pellegrini was appointed to power.
Vedernikov M.
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Late cenozoic history of the genus Micromys (mammalia, rodentia) in Central Europe. [PDF]

PLoS ONE, 2013
Molecular phylogeography suggests that Micromys minutus, the sole extant species of the genus, colonized its extensive range quite recently, during the Late Pleistocene-Holocene period.
Ivan Horáček, Markéta Knitlová, Jan Wagner, László Kordos, Adam Nadachowski   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Syndrome of an Emigrant: Memory, Trauma, Longing, and Loss in the Art of Józef Czapski [PDF]

Athens Journal of Humanities & Arts
This article addresses the multilayered thematic area focused on the impact of trauma, caused by war and political oppression, on the attitudes of artists who followed combat trails and migration routes to ultimately settle far from their homeland.
Irena Kossowska
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Provincializing for a Planetary Perspective

Práticas da História, 2020
The article takes its point of departure from the dynamics between Enlightenment modernity as it unfolds from the perspective of Marx (History 1 in Provincializing Europe) and the corrective counter-narratives, in the form of a protest against the former,
Bo Stråth
doaj   +3 more sources

(IN)VISIBLE TRACES: THE PRESENCE OF THE RECENT PAST IN THE URBAN LANDSCAPE OF SARAJEVO

Місто: історія, культура, суспільство, 2018
The author reflects on her observations during the summer school ‘History Takes Place – Dynamics of Urban Change.’ She discusses the number of locations, which embodied or recalled the memories of war and siege of the city, both those that remained from
Natalia Otrishchenko
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source