Results 51 to 60 of about 168,529,466 (299)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The Syndrome of an Emigrant: Memory, Trauma, Longing, and Loss in the Art of Józef Czapski [PDF]
Athens Journal of Humanities & ArtsThis article addresses the multilayered thematic area focused on the impact of trauma, caused by war and political oppression, on the attitudes of artists who followed combat trails and migration routes to ultimately settle far from their homeland.
Irena Kossowska
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
(IN)VISIBLE TRACES: THE PRESENCE OF THE RECENT PAST IN THE URBAN LANDSCAPE OF SARAJEVO
Місто: історія, культура, суспільство, 2018 The author reflects on her observations during the summer school ‘History Takes Place – Dynamics of Urban Change.’ She discusses the number of locations, which embodied or recalled the memories of war and siege of the city, both those that remained from
Natalia Otrishchenko
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Hierarchy of Governance Institutions and the Pecking Order of Privatisation: Central-Eastern Europe and Central Asia Reconsidered [PDF]
, 2008 We discuss property rights, corporate governance frameworks and privatisation outcomes in the Central Eastern Europe and Central Asia (CEECA) region.
Tomasz M. Mickiewicz, Mickiewicz, T
core +1 more source
Civil society and state security in Central Europe, 1770-1830
, 2022 Brophy, James M.Based upon police reports and other state documents from six regional and state archives in Germany and Austria, this study traces evolving state responses to new, radical ideas and forms of political participation over three historical ...
Haidinger, Brendan W.
core +1 more source
Provincializing for a Planetary Perspective
Práticas da História, 2020 The article takes its point of departure from the dynamics between Enlightenment modernity as it unfolds from the perspective of Marx (History 1 in Provincializing Europe) and the corrective counter-narratives, in the form of a protest against the former,
Bo Stråth
doaj +3 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source