Results 71 to 80 of about 1,652,481 (345)

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Poland and Poles in the Biography of Carl Gustaf Emil Mannerheim

Journal on European History of Law, 2012
The biography of Marshal of Finland C. G. Mannerheim Poland and the Poles didn’t play important role. Despite this it can be concluded that in the first period of his adult life he had very close contacts with them.
Marek Białokur
doaj  

East Central Europe in the First Globalization (1850-1914)

Studia Historiae Oeconomicae, 2019
The article analyzes the position and the positioning strategy of East Central Europe in the so-called “first globalization (1850-1914)”. The focus is on foreign trade and the transfer of the two most important production factors, i.e. capital and labor.
Uwe Müller
doaj   +1 more source

(Inter)national Recording Histories of Central Europe

Studia Musicologica
AbstractThe early international record companies considered Central Europe to be a more or less unified market, both before and after the fall of the Austro-Hungarian Empire. The Gramophone Company created a separate catalog for the “non-German” language recordings of the Austro-Hungarian Empire and some neighboring states, and assigned the territory ...
openaire   +2 more sources

Development of organic animal production in Turkey [PDF]

, 2004
Turkey is located at a point where the three continents are making up the old world. Europe, Asia and Africa are close to each other thus, making it is a pre-eminent centre of commerce for centuries.
Polat, Muazzez, Sayan, Yilmaz
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Chernozem. From concept to classification: a review

Acta Universitatis Carolinae Geographica, 2016
In this paper, we put together the most important facts that lead to the research on chernozem. Thanks to the work of V. V. Dokuchaev (1846–1903), chernozem stands at the forefront of pedology. In 1883, Dokuchaev introduced the first concept of chernozem:
Barbora Vysloužilová, Damien Ertlen, Dominique Schwartz, Luděk Šefrna   +3 more
doaj   +1 more source

The Historical Development of the Port of Livorno (Italy) and Its New Port Plan 2010 in Advanced Stage of Elaboration [PDF]

, 2011
The geographical location makes the port of Livorno one of the most important in Italy. The port, in fact, benefits of an extended network of roads and rails connecting it with the rest of Italy, and central and southern Europe as well.
A. Del Corona, A. Noli, C. Vanni, DE GIROLAMO, Paolo, M. Tartaglini   +4 more
core   +1 more source