Results 141 to 150 of about 3,421,831 (294)
History of Construction Cultures [PDF]
, 2021 João Mascarenhas-Mateus +3 more
openaire +2 more sources
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
A Monument to Culture and Achievement: The Samurai Suit of Armor and Katana at Gettysburg College [PDF]
, 2018 Of the many artifacts found in Gettysburg College’s Musselman library, perhaps the most unusual and seemingly out of place may be the centuries-old replica of a samurai suit and katana standing guard over visitors and students from an oversized glass ...
Hauk, Carolyn
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Religion, Culture and Habits: Boundaries Within a Global Village [PDF]
, 2008 McLuhan’s idea of a “global village” theory is idealistic. It assumes that the globe shares a single history, economy, and culture. Whereas a common history and economy are arguably present, a shared culture is less realistic.
Rickart, Tessa
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Closing the Gap: A Research Agenda for the Study of Health Needs among American Indian/Native Hawaiian Transgender Individuals [PDF]
, 2013 Objectives: To explore health research needs of American Indian and Native Hawaiian (AIINH) transgender individuals. Methods: This qualitative study is composed of four focus groups and one informal meeting, totaling 42 AIINH transgender individuals in ...
Jackson, Trudie, Vernon, Irene S
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Haiyang Kaifa yu guanliHomestay is an important business model in the tourism industry and a crucial tool for rural revitalization. In recent years, there have been signs of it blooming everywhere.
WU Xiaowei +3 more
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