Results 121 to 130 of about 6,995,982 (396)

A educação paraibana da colônia a nossos dias: uma abordagem histórica

Psicologia Escolar e Educacional
O artigo apresenta o contexto histórico da evolução da educação e do sistema educacional na Paraíba, um dos estados brasileiros. Os temas considerados são: escolas profissionalizantes; perspectivas teóricas; escolas históricas; ciclos históricos e ...
José Octávio de Arruda Mello
doaj  

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

The Technological Education Institutes (TEI) in Greece and their libraries [PDF]

, 1999
The legal framework for the foundation of the Technological Education Institutes (TEI) in Greece is presented. A short history of the education of the librarians in Greece and some general information about all the Institutes and their libraries is ...
Elissaiou, Anastasia, Sioki, Kalliopi, Sitas, Anestis   +2 more
core  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Business Activity in Mediterranean Sea and its Impact on Crusades Emirates in Levant Country fell during the second half of seventh century(A.H.)

الأستاذ, 2018
       The commercial activity in the Mediterranean had a major impact in Emirates Crusades in Levant country fell by Al- Mamluks hand , however , the competition was at its peak between the European Emirates particularly among Italian republics marine ,
Dr.Nihad Hameed ELaibi Aged, Dr.Ragheed Gummar Majeed Salman   +1 more
doaj   +1 more source

The New York Public School: Being a History of Free Education in the City of New York [PDF]

, 1905
A. Emerson Palmer
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Foucauldian Peacekeeping: On the Dispersion of Power and the Futility of Change [PDF]

, 2009
Foucault is widely known for the radical nature of his work, for his idiosyncratic approach to history, and for his reconfiguration of the concept of power. Curiously though, his conceptions of history and power might act to undermine their potential to
Allen, Ansgar
core   +1 more source