Results 101 to 110 of about 4,530,314 (306)

Educating through Exemplars: Alternative Paths to Virtue [PDF]

, 2017
This paper confronts Zagzebski’s exemplarism with the intertwined debates over the conditions of exemplarity and the unity-disunity of the virtues, to show the advantages of a pluralistic exemplar-based approach to moral education (PEBAME).
Annas J, Bandura A, Bandura A, Deaglio E, Foot P, Irwin T, Kristjánsson K, Lovibond S, Maria Silvia Vaccarezza, McDowell JH, Michel Croce, Murdoch I, Murdoch I, Nagel T, Nussbaum M, Polisportiva Gagliarda, Russell D, Steutel J, Urmson JO, Williams B, Zagzebski LT, Zagzebski LT   +21 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Scientometric Analysis on the Ethics Education in the COVID-19 Era for Pure Life (2020-2024) [PDF]

International Multidisciplinary Journal of Pure Life
SUBJECT & OBJECTIVES:  Sometimes, the boundaries of ethics have been broken in online education, and COVID-19 has unconsciously provided the necessary grounds for this tension.
Amir Karimi, Fatemeh Sharifi, Kourosh Fathi, Ika Maryani, Khairul Hafezad Abdullah   +4 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The Influence of Temple Monopoly (TEMON) Game on Historical Thinking Skills and Learning Independence in History Learning at SMA Negeri 4 Bekasi

Mimbar Ilmu
A common problem in Indonesia, especially in history learning, is the one-way (teacher-centered) lecture method, which results in non-interactive classes, lack of student independence, and limited improvement in student skills.
Sidqi Alfarez, Fakhruddin M, Kurniawati
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A educação paraibana da colônia a nossos dias: uma abordagem histórica

Psicologia Escolar e Educacional
O artigo apresenta o contexto histórico da evolução da educação e do sistema educacional na Paraíba, um dos estados brasileiros. Os temas considerados são: escolas profissionalizantes; perspectivas teóricas; escolas históricas; ciclos históricos e ...
José Octávio de Arruda Mello
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Evolution of Collaboration Skills Research in Education : Trends, Intellectual Structure, and Research Topics

Jurnal Kependidikan
This study aims to examine the evolution of collaboration skills in the field of education including publication trends, intellectual structure, and research topics.
Diah Galuh Kusumarti, Sariyatun Sariyatun, Triana Rejekiningsih   +2 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source