Results 61 to 70 of about 6,995,982 (396)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

L’école qui vient : éducation ou médiation ? La recomposition postmoderne, entre verticalité et horizontalité

Recherches en Éducation, 2007
La crise des « grands récits » touche de plein fouet une école dont l’idée et les valeurs sont comme on le sait intimement liées à la modernité. L’école réelle n’en continue pas moins de « marcher » comme elle peut, entre bricolage postmoderne et ...
Alain Kerlan
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

TPACK Research Trends in Indonesia: Contributions to Enhancing the Equivalency Education History Teacher Community

Journal of Nonformal Education
Background: Technological Pedagogical Content Knowledge (TPACK) is a vital framework for integrating technology into education. In Indonesia, TPACK research has grown significantly, yet most studies focus on science and mathematics, leaving gaps in ...
Leo Agung Sutimin, Sariyatun Sariyatun, Akhmad Arif Musadad, Tri Yuniyanto, Nur Fatah Abidin   +4 more
doaj   +1 more source

Resisting Return to Dutch Colonial Rule: Political Upheaval after Japanese Surrender during the Independence Movement in Sulawesi, Indonesia

Histories, 2022
Central Sulawesi is a part of Indonesia with a fascinating history during the revolutionary period (1945–1950), owing to several important events related to Indonesian sovereignty.
Lukman Nadjamuddin, Amar Ali Akbar, Adrian Perkasa, Farida R. Wargadalem, Wilman D. Lumangino   +4 more
doaj   +1 more source

Vulnerability to bullying in children with a history of specific speech and language difficulties [PDF]

, 2008
This is an electronic version of an article published in Lindsay, Geoff and Dockrell, Julie and Mackie, Clare (2008) Vulnerability to bullying in children with a history of specific speech and language difficulties.
Ahmad Y., Arora C.M.J., Bishop D.V.M., Brinton B., Clare Mackie, Craig W.M., Dunn L.M., Elliott C.D., Fujiki M., Geoff Lindsay, Harter S., Julie E. Dockrell, Leonard L.B., Martlew M., Neale M., Olweus D., O’Moore A.M., Plante E., Redmond S., Renfrew K., Seals D., Semel E., Smith P.   +22 more
core   +2 more sources

History Of Rigor: A Review Of 20th Century Science Education [PDF]

arXiv, 2020
"Rigor" is an often sought after but ill-defined concept in education. This work reviews several models of rigor from current literature before proposing a tool which is used to analyze science education throughout history. The 20\textsuperscript{th} century science education in the United States was subject to changing sociopolitical motivations about
arxiv  

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

UNESCO Strategy and Digital Policies for Teacher Training: The Deconstruction of Innovation in Spain

Journal of New Approaches in Educational Research, 2022
This paper examines initial teacher training policies in the context of youth digitalisation. Based on international ICT competency frameworks for teachers (UNESCO, 2008, 2019) and information literacy, MIL (UNESCO, 2011), we analyse how Spanish (public ...
Lourdes Belén Espejo Villar, Luján Lázaro Herrero, Gabriel Álvarez López   +2 more
doaj   +1 more source

How did we get here? A brief history of competency‐based higher education in the United States

, 2016
Background Competency-based education (CBE) programs have spread briskly in higher education over the past several years and their trajectory continues to rise.
T. Nodine
semanticscholar   +1 more source