Results 71 to 80 of about 1,200,460 (313)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Digitalizing History: Development of E-Module for History Learning on the Subject of Japanese Colonialism Period in Indonesia

JINOP (Jurnal Inovasi Pembelajaran)
This study aims to investigate the effectiveness of using e-module teaching materials in history education. This study is development research conducted using direct observation techniques and the distribution of questionnaire surveys to the research ...
Muhammad Reza Arviansyah, Sani Safitri, Syarifuddin Syarifuddin, Alfiandra Alfiandra   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Developing an understanding of the Kanadier Mennonite and implications for education [PDF]

, 2000
vii, 158 leaves ; 29 cm. --The project focuses on a unique migrant population in Horizon School Division called the Kanadier Mennonites. The Kanadier Mennonites who depart Mexico and other Latin American countries present a number of educational ...
Gilmore, Cheryl Anne, University of Lethbridge. Faculty of Education   +1 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Swimming with arms only an examination of the life and professional practices of a special education teacher with special needs [PDF]

, 2002
ix, 127 leaves ; 29 cm. --This project is a journey of both personal and professional reflection that spans over a period of forty-five years. I have attempted to document my life under the consideration of the themes that surfaced while writing ...
Hodgson, Charlene, University of Lethbridge. Faculty of Education   +1 more
core  

CURRENT STATE OF HISTORIC AND EDUCATIONAL RESEARCH

Sovremennye Issledovaniâ Socialʹnyh Problem, 2013
In this paper we analyze the results of development of national historic and educational research at the turn of the XXth century; pinpoint obvious success and indicate problems and contradictory areas; give grounding to the development model of the XXth
Тимур Альбертович Магсумов
doaj  

Development of Evernoted Learning Media Center as Learning Innovation and Assistive Technology for People with Disabilities

Jurnal Teknologi Pendidikan
The development of Evernoted Learning Media Center aims to introduce inclusive learning innovations for people with disabilities. This study presents the design and implementation of an Evernoted-based learning platform with accessibility features ...
Riski Agung Novarianto, Prihma Utami, Ferdinan Bashofi, Septa Rahadian, Puspita Pebri Setiani, Faizah Ulumi Firdausi, Nurcholis Sunuyeko   +6 more
doaj   +1 more source