Results 111 to 120 of about 1,470,492 (332)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Análisis semiológico de la revista de modas romántica.
Estudios sobre el Mensaje Periodístico, 2001 Sin ...
Pablo Pena
doaj
Aisthema: International Journal, 2021 This paper presents a reconstruction and interpretation of the process of change in Adam Smith’s philosophy basing on the example of changes in fashion. I shall focus on the role of imagination, as well as on the role of the wealthy in the process.
Anna Markwart
doaj
Power Play and Performance in Harajuku
New Voices, 2011 This article analyses the structures and implications of Japan’s contemporary street fashion cultures, primarily those of Harajuku. Using Roland Barthes’ analogy of dress and dressing it situates the radical subcultural styles within traditional Japanese
Amelia Groom
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Punishment in Pre-Colonial Indigenous Societies in North America [original paper] [PDF]
, 1987 A revised version of this paper was published in the "proceedings" volume for this conference: Conn, Stephen. (1991). "Punishment in Pre-Colonial Indigenous Societies in North America." La peine, Quatrième partie.
Conn, Stephen
core
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source