Results 31 to 40 of about 317,424 (303)

Women in Canadian Science and Technology before World War I: their Publication Record [PDF]

open access: yes, 1988
Little has been written about the work of women in Canadian science and technology, particularly for the period prior to the First World War. In this study, drawing largely on data in Science and Technology in Canadian History: A Bibliography of Primary ...
MacDonald, Bertrum H., Chu, Clara M.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

From interventions to interactions: Science Museum Arts Projects’ history and the challenges of interpreting art in the Science Museum [PDF]

open access: yesJCOM: Journal of Science Communication, 2009
Hannah Redler’s paper examines the 13 year history of Science Museum, London’s contemporary art programme and explores how changing cultural conditions and the changing function of museums are making the questions raised by bringing art into the Science ...
Hannah Redler
doaj  

History of formation and development of biostatistics

open access: yesАктуальні питання суспільних наук та історії медицини, 2022
The history of the formation and development of biostatistics. In the last 20-30 years, medicine and biology have entered a new phase of their development.
Anzhela Biduchak   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Technology in Canada Through the Lens of Labour History [PDF]

open access: yes, 1991
This is an extended review essay which examines contributions of recent labour history to the history of Canadian technology. It argues that three recent books: Heron's Working in Steel, Sager's Seafaring Labour, and Parr's Gender of Breadwinners have ...
Lutz, John
core   +1 more source

Health QR Code Application in the Novel Containment Strategy and Healthcare Plan for Pregnant Women and Children Under Quarantine During the Summer Outbreak of SARS-CoV-2 Delta Variant in Chengdu, China: An Observational Study

open access: yesRisk Management and Healthcare Policy, 2021
Shan Chen,1,* Tianjiao Liu,1,2,* Xin Li,2,* Yingjuan Luo,3 Li Xiao,1 Libing Zhang,4 Rongkang Wen,3 Yonghong Lin2 1The Medical Administration Department, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of ...
Chen S   +7 more
doaj  

Media in Action: From Exorcism to Mesmerism

open access: yescommunication +1, 2015
In the Bavaria of 1775, the popular exorcist practices performed by the catholic priest Johann Joseph Gassner were discredited and superseded by the enlightened, ‘scientific’ system of Franz Anton Mesmers “Animal Magnetism”.
Stephan Gregory
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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