Results 51 to 60 of about 335,151 (252)

Women in Canadian Science and Technology before World War I: their Publication Record [PDF]

, 1988
Little has been written about the work of women in Canadian science and technology, particularly for the period prior to the First World War. In this study, drawing largely on data in Science and Technology in Canadian History: A Bibliography of Primary ...
MacDonald, Bertrum H., Chu, Clara M.
core   +1 more source

World Association for the History of Veterinary Medicine 44th International Congress : 27-29 February 2020, The Farm Inn Hotel and Conference Centre, Pretoria, South Africa : proceedings [PDF]

, 2020
Presentation delivered at the 44th International Congress of the World Association for the History of Veterinary Medicine held from the 27-29 of February 2020 at The Farm Inn Hotel and Conference Centre, Pretoria, South AfricaThis paper emphasizes the ...
Welk-Joerger, Nicole
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Critiquer les sciences et la médecine dans un pays non hégémonique

Revue d'anthropologie des connaissances, 2012
The years 1960 and 1970 in many industrialized countries, are times of a large dissent movement on scientific and technological development. Controversies (pesticides, nuclear energy, asbestos) multiply and some groups are questioning radically against ...
Mathieu Quet
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

MSc studentships in the History of Medicine Centre for the History of Science, Technology and Medicine (CHSTM)

, 2011
MSc studentships in the History of Medicine Centre for the History of Science, Technology and Medicine (CHSTM) The University of Manchester http://www.chstm.manchester.ac.uk/ The Centre invites studentship applications for the History of Medicine route ...
corpsetmedecine
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Technology in Canada Through the Lens of Labour History [PDF]

, 1991
This is an extended review essay which examines contributions of recent labour history to the history of Canadian technology. It argues that three recent books: Heron's Working in Steel, Sager's Seafaring Labour, and Parr's Gender of Breadwinners have ...
Lutz, John
core   +1 more source