Results 71 to 80 of about 335,151 (252)
Criticism as culture: Above the first History of Serbian Literature Pavel Josef Safarik [PDF]
Baština, 2020 The first History of Serbian Literature (1865) was written from the PEN of P. J. Safarik (1796-1861), a foreigner, who lived and worked in Novi Sad and did not write in Serbian. The final form was given by Safarik's son-in-law, who made some changes. The
Mumović Ana M.
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
History of Science is devoted to the history of science, medicine and technology from earliest times to the present day. Articles discussing methodology, and reviews of the current state of knowledge and possibilities for future research, are especially ...
GUAGNINI, ANNA
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A consumer study evaluating the extent technology education textbooks use 1993 benchmarks for science literacy [PDF]
, 1999 Plan BA review of how well introductory technology education textbooks incorporate the 1993 Benchmarks for Science Literacy were investigated. Important technology education definitions, readability, organization of content and actual substantive ...
Johnson, Douglas Alan
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Open Access Rheumatology: Research and Reviews, 2020 Ali A Al-Omari,1 Anas AR Altamimi,2 Esra’a ALQuran,3 Abed Allah Ahmad Saleh,1 Qusai Mustafa Alyafawee,1 Mohammad Ziad Audat,4 Khaldoon Bashaireh1 1Department of Special Surgery, Division of Orthopedics, Faculty of Medicine, Jordan University of ...
Al-Omari AA +6 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source