Results 81 to 90 of about 335,151 (252)

History of Science

, 2005
This seminar explores recent historiographical approaches within the history of science. Students will read a wide variety of studies covering topics from the seventeenth through the twentieth centuries, from the physical sciences to natural history and ...
Jones, David
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

How medicine could have developed differently: A Tory historiographical analysis of the conflict between allopathic and homoeopathic medicine in America and Britain from 1870 to 1920. [PDF]

, 2007
After its formulation by Samuel Hahnemann (1755-1843) at the end of the 18th century, homoeopathy spread to Britain and America in the 1820ร. Based upon the principle or law of "similia similibus curentur"- let like be cured by like-homoeopathy presented
Brierley-Jones, Lynda Karen
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Fractures: A History and Philosophy of Patient Suffering in 20th-century American Medicine [PDF]

, 2022
My dissertation explores the history and philosophy of patient suffering in 20th-century American medicine. Chapter One argues that historians of medicine colloquially synonymize suffering with related phenomena, such as pain, which risks treating ...
Duffee, Charlotte
core  

Lesion Type Analysis of Hemodialysis Patients Who Underwent Endovascular Management for Symptomatic Central Venous Disease

Vascular Health and Risk Management, 2020
Qusai Aljarrah,1 Mohammed Allouh,2 Amer H Hallak,3 Shamikh E Alghezawi,3 Mamoon Al-Omari,4 Mwaffaq Elheis,4 Mooath Al-Jarrah,4 Sohail Bakkar,5 Abdelwahab J Aleshawi,6 Hussam Al-Jarrah,1 Khalid S Ibrahim,7 Jan Mohammed Al Shishani,8 Aws Almukhtar9 ...
Aljarrah Q, Allouh M, Hallak AH, Alghezawi SE, Al-Omari M, Elheis M, Al-Jarrah M, Bakkar S, Aleshawi AJ, Al-Jarrah H, Ibrahim KS, Al Shishani JM, Almukhtar A   +12 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Related Risk Factors That Predict Moderate to Severe Asthma Attack in Children: Analysis Based on Logistic Regression and Decision Tree

International Journal of General Medicine
Qianqian Li, Yinghong Fan, Ronghua Luo, Jie Hu, Li Wang,* Tao Ai* Pediatric Respiratory Medicine Department, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China ...
Li Q, Fan Y, Luo R, Hu J, Wang L, Ai T
doaj  

A Preliminary Discussion on the Research Methods of the Interpretation of Classical Texts in Traditional Chinese Medicine

Yixue yu zhexue
In modern era, Traditional Chinese Medicine (TCM) has continuously sought viable developmental pathways amid the challenges posed by Western medicine and persistent questions regarding its scientific status.
Minmin YAN, Zuozhen HUANG, Man GU
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source