Results 61 to 70 of about 317,424 (303)

Acute Basophilic Leukemia Arising from Chronic Myeloid Leukemia with +8, I(17q)(q10) and der(22)t(9;22) After Imatinib Therapy

open access: yesJournal of Blood Medicine, 2023
Peng Shan,1,2 Hang Dong,1,2 Shilan Li3 1Department of Laboratory, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, People’s Republic of China; 2Core Unit ...
Shan P, Dong H, Li S
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Colonial Agro-Industrialism: Science, Industry and the State in the Dutch Golden Alkaloid Age, 1850-1950

open access: yes, 2015
This thesis is about what I call the Dutch Golden Alkaloid Age between roughly the 1850s and 1950s. I follow the historical trajectory of the production and distribution of the anti-febrifuge cinchona bark tree (Cinchona officinalis Lin.) and its most ...
Sub History and Philosophy of Science   +2 more
core  

How medicine could have developed differently: A Tory historiographical analysis of the conflict between allopathic and homoeopathic medicine in America and Britain from 1870 to 1920. [PDF]

open access: yes, 2007
After its formulation by Samuel Hahnemann (1755-1843) at the end of the 18th century, homoeopathy spread to Britain and America in the 1820ร. Based upon the principle or law of "similia similibus curentur"- let like be cured by like-homoeopathy presented
Brierley-Jones, Lynda Karen
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Patrick Manning and Mat Savelli (eds), Global Transformations in the Life Sciences, 1945–1980

open access: yes, 2020
The question of whether science is a global enterprise has been settled, but the question of how to narrate the history of science in a global frame remains open.
Scheffler, Robin W
core   +1 more source

Socio-Demographic Factors and Other Predictors of Pap Test Uptake Among Women: A Retrospective Study in Ghana

open access: yesCancer Management and Research, 2023
Kofi Boamah Mensah,1 Adwoa Bemah Boamah Mensah,2 Peter Yamoah,3 Jennifer Manfo,4 Richmond Amo,5 Ebenezer Wiafe,6 Neelaveni Padayachee,7 Varsha Bangalee8 1Department of Pharmacy Practice, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana ...
Mensah KB   +7 more
doaj  

Criticism as culture: Above the first History of Serbian Literature Pavel Josef Safarik [PDF]

open access: yesBaština, 2020
The first History of Serbian Literature (1865) was written from the PEN of P. J. Safarik (1796-1861), a foreigner, who lived and worked in Novi Sad and did not write in Serbian. The final form was given by Safarik's son-in-law, who made some changes. The
Mumović Ana M.
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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