Results 91 to 100 of about 5,700,334 (377)
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Philosophy of Experimental Biology [PDF]
, 2009 Philosophers have committed sins while studying science, it is said – philosophy of science focused on physics to the detriment of biology, reconstructed idealizations of scientific episodes rather than attending to historical details, and focused on ...
Stegenga, Jacob
core +3 more sources
Positive Sciences at the International Congress of History [PDF]
, 1903 Piero Giacosa
openalex +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
The History and Science of the Major Birch Pollen Allergen Bet v 1. [PDF]
Biomolecules, 2023 Breiteneder H, Kraft D.
europepmc +1 more source
Natural Science in Hygiene, or the Life-History of the Non-Bacterial Parasites affecting Man [PDF]
, 1906 R. T. HEWLETT
openalex +1 more source
Protein kinase FAM20C—when subcellular localization matters
FEBS Letters, EarlyView.FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley +1 more source
The Electrophoretic Revolution in the 1960s: Historical Epistemology Meets the Global History of Science and Technology. [PDF]
Ber Wiss, 2022 Suárez-Díaz E.
europepmc +1 more source
History of Science and Technology in India and South-East Asia [PDF]
, 1951 Joseph Needham
openalex +1 more source