Results 121 to 130 of about 180,398,810 (309)
Proceedings of the Arizona-Nevada Academy of Science, Volume 05 (1968)
, 1968 FIFTH ANNUAL MEETING / May 10-11, 1968 / Northern Arizona University / Flagstaff, ArizonaThis volume is part of the Arizona-Nevada Academy of Science collections.
Arizona-Nevada Academy of Science
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Proceedings of the Arizona-Nevada Academy of Science, Volume 29 (1994)
, 1994 THIRTY-EIGHTH ANNUAL MEETING / April 16, 1994 / Glendale Community College / Glendale, ArizonaThis volume is part of the Arizona-Nevada Academy of Science collections.
Arizona-Nevada Academy of Science
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Proceedings of the Arizona-Nevada Academy of Science, Volume 10 (1975)
, 1975 NINETEENTH ANNUAL MEETING / April 11-12, 1975 / Joint Meeting with Arizona State University / Tempe, Arizona / Abstracts from the annual meeting of the Arizona-Nevada Academy of Science.This volume is part of the Arizona-Nevada Academy of Science ...
Arizona-Nevada Academy of Science
core
Communicating the Heisenberg uncertainty relations: Niels Bohr, Complementarity and the Einstein-Rupp experiments [PDF]
, 2015 The Einstein-Rupp experiments have been unduly neglected in the history of quantum mechanics. While this is to be explained by the fact that Emil Rupp was later exposed as a fraud and had fabricated the results, it is not justified, due to the importance
Sub History and Philosophy of Science +3 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source