Results 131 to 140 of about 1,534,315 (310)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Integrating the history of science into broader discussions of research integrity and fraud. [PDF]
Hist Sci, 2020 Roberts LL, Sibum HO, Mody CCM.
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
History and 50th Anniversary Program, 1908-1958 Mortuary Science Department
, 1958 University of Minnesota. Program of Mortuary Science. (1958). History and 50th Anniversary Program, 1908-1958 Mortuary Science Department.
University of Minnesota. Program of Mortuary Science
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Measurement, self-tracking and the history of science: An introduction. [PDF]
Hist Sci, 2020 Sysling F.
europepmc +1 more source
The History of Science and Theology
, 2022 This entry offers a history of the different ways in which the formal study of the natural world has been related to theological considerations in the Western Christian tradition. Because what counts as science and what counts as theology has changed over time, it begins with a history of the concepts ‘theology’ and ‘science’ and the bearing of these ...
openaire +2 more sources
Reichenbach: Probability & the A Priori: Has the Baby Been Thrown out with the Bathwater?
, 2017 Throughout the work of the early 20th century philosopher/physicist Hans Reichenbach there are traces of Kantian philosophy. These traces can also be found within Reichenbach’s mature, logical positivist, writings.
Sub History and Philosophy of Science +2 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source