Results 91 to 100 of about 1,889,906 (345)

NORMATIVE ISSUES IN MARGINALISM: THE CASE OF P. WICKSTEED [PDF]

Phillip Wicksteed’s ideas played an important role in the history of economic methodology. This is because of two reasons: The first was that his views represent the starting point of the deliberate attempt to expel normative issues from marginalist ...
Drakopoulos, Stavros A.
core   +1 more source

Digital Genesis: Computers, Evolution and Artificial Life [PDF]

, 2015
The application of evolution in the digital realm, with the goal of creating artificial intelligence and artificial life, has a history as long as that of the digital computer itself.
Dorin, Alan, Korb, Kevin, Taylor, Tim
core  

Évora Studies in the Philosophy and History of Science Volume Two From Ontology To Structure [PDF]

, 2018
The structuralist approaches retake the war, characteristic of ancient Greek thought, between the partisans of matter and the ‘friends of ideas’, although they abandon the metaphysical and ontological issues, thus favouring the methodological aspects of ...
Paz, María de, Príncipe, João
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Science and History of Science: between Comte and Canguilhem

Transversal: International Journal for the Historiography of Science, 2018
In the present article, we discuss the specificity of the object of the history of science as an autonomous and interdisciplinary field of studies by nature and origin, placed at the interface of history, epistemology and science, and focus on some key ...
Márcia H. M. Ferraz, Ana M. Alfonso-Goldfarb, Silvia Waisse   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The Curated 'UNESCO Courier' 1.0: Annotated Corpora for Digital Research in the Global Humanities

Journal of Open Humanities Data
The monthly magazine of the United Nations Educational, Scientific and Cultural Organization, founded in 1948 as The UNESCO Courier, represents an extraordinary resource for research on global themes in the humanities. We present the Curated Courier 1.0,
Benjamin G. Martin, Fredrik Mohammedi Norén, Roger Mähler, Andreas Marklund, Oriane Martin   +4 more
doaj   +1 more source

Reactor Neutrino Experiments: Present and Future

, 2017
Reactor neutrinos have been an important tool for both discovery and precision measurement in the history of neutrino studies. Since the first generation of reactor neutrino experiments in the 1950s, the detector technology has been greatly advanced. New
Cao, Jun, Wang, Yi-Fang, Wen, Liang-Jian
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

UNESCO’s Proceedings, 1945–2017: A Bilingual Digital Text Corpus

Journal of Open Humanities Data
The record of the meetings of UNESCO’s General Conference offers a valuable resource for research in the global humanities. We present a digital text corpus, including metadata and supplementary material, that makes the complete record of these meetings ...
Benjamin G. Martin, Fredrik Mohammedi Norén, Roger Mähler, Andreas Marklund, Oriane Martin   +4 more
doaj   +1 more source