Results 41 to 50 of about 1,074,136 (335)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

«Standing beneath the window with my Guitar...»: History and Modernity of Spanish Tuna

RUDN Journal of World History, 2012
This article studies Spanish tuna as a centuries-old tradition of student singing accompanied by the playing on traditional music instruments. The authors present the main features of the modern tuna, research and describe the history of its origin and ...
G Aleksandrovna Khimich, A Aleksandrovna Basmanova   +1 more
doaj  

Patients’ and Professionals’ Views on Managing Fibromyalgia

Pain Research and Management, 2013
BACKGROUND: Managing fibromyalgia is a challenge for both health care systems and the professionals caring for these patients, due, in part, to the fact that the etiology of this disease is unknown, its symptoms are not specific and there is no ...
Erica Briones-Vozmediano, Carmen Vives-Cases, Elena Ronda-Pérez, Diana Gil-González   +3 more
doaj   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Retreating to nature : rethinking 'therapeutic landscapes' [PDF]

, 2008
There is a long history of removing oneself from ‘society’ in order to recuperate or repair. This paper considers a yoga and massage retreat in Southern Spain, and what opportunities this retreat experience might offer for recuperation and the creation ...
Braun B, Dewsbury J D, Gesler W, Latour B, Lea J, Lorraine T, Massey D, Philo C, Probyn E, Scaravelli V, Serres M, Shorter E, Smith M, Smith M, Smith M, Thrift N, Whatmore S   +16 more
core   +1 more source

Souffrant d’« insouffrables » souffrances : espaces et représentations de la douleur dans la dernière maladie de Philippe II (été 1598)

Histoire, Médecine et Santé, 2022
The last illness of Philip II (summer 1598) is a privileged observatory to reflect, in a historical and situated perspective, on the suffering caused by the pain of others in the 16th century.
Elisa Andretta
doaj   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

The Demands of Niqabi Women in the Telegram Subaltern Corner Orgullo Niqabi

Social Inclusion, 2020
The present article is about Niqabi women belonging to the private Telegram instant messaging channel Orgullo Niqabi (Spanish for ‘Niqabi Pride’). More specifically, our main objective is to explain what they are demanding, how they articulate their ...
Alexandra Ainz-Galende, Rubén Rodríguez-Puertas   +1 more
doaj   +1 more source

An account on the history of pharmacology in Spain

Pharmacological Research
Here we present an account on the history of pharmacology in Spain. Pharmacology as an independent science in Europe began with the creation of university chairs. Of particular relevance was the appointment in 1872 of Osswald Shmiedeberg as chairman of an Institute of Pharmacology at the University of Strassbourg, Germany. Teófilo Hernando pioneered in
Ana María Aldea-Perona, Jesús Flórez Beledo, Jesús Frías Iniesta, Antonio G. García, Juan Tamargo, Francisco Zaragozá   +5 more
openaire   +3 more sources