Results 71 to 80 of about 167,702,766 (324)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

«Standing beneath the window with my Guitar...»: History and Modernity of Spanish Tuna

open access: yesRUDN Journal of World History, 2012
This article studies Spanish tuna as a centuries-old tradition of student singing accompanied by the playing on traditional music instruments. The authors present the main features of the modern tuna, research and describe the history of its origin and ...
G Aleksandrovna Khimich   +1 more
doaj  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

The influence of lifestyle, diet, and reproductive history on age at natural menopause in Spain: Analysis from the EPIC‐Spain sub‐cohort

open access: yesAmerican Journal of Human Biology, 2018
To determinate the role of lifestyle factors, recent diet, menstrual factors, and reproductive history in age at natural menopause in adult Spanish women.
L. Luján-Barroso   +12 more
semanticscholar   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

open access: yesFEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima   +7 more
wiley   +1 more source

Patients’ and Professionals’ Views on Managing Fibromyalgia

open access: yesPain Research and Management, 2013
BACKGROUND: Managing fibromyalgia is a challenge for both health care systems and the professionals caring for these patients, due, in part, to the fact that the etiology of this disease is unknown, its symptoms are not specific and there is no ...
Erica Briones-Vozmediano   +3 more
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan   +14 more
wiley   +1 more source

The Demands of Niqabi Women in the Telegram Subaltern Corner Orgullo Niqabi

open access: yesSocial Inclusion, 2020
The present article is about Niqabi women belonging to the private Telegram instant messaging channel Orgullo Niqabi (Spanish for ‘Niqabi Pride’). More specifically, our main objective is to explain what they are demanding, how they articulate their ...
Alexandra Ainz-Galende   +1 more
doaj   +1 more source

Construction History in Spain

open access: yes, 2015
En Espagne, l’histoire de la construction constitue une discipline à part entière, consolidée durant ces vingt dernières années en raison des nombreuses manifestations dédiées. Mais des obstacles pourraient la menacer : l’absence d’enseignement, l’amateurisme et la fragmentation. L’enseignement est envisagé dès la formation initiale.
Huerta Fernández, Santiago   +1 more
openaire   +2 more sources

The Natural History of Illinois: Illinois State Laboratory of Natural History Bulletin Volume 1 no. 2 [PDF]

open access: yes, 1878
This is the second of a series of publications, issued by authority of the State Board of Education of Illinois, and designed especially to elucidate the natural history of this State. The first number was published in December, 1876, as Bulletin No.
Illinois State Laboratory of Natural History
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