Results 81 to 90 of about 921,158 (313)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Reconstructing the invention of the wheel using computational structural analysis and design
Royal Society Open ScienceThe invention of the wheel is widely credited as a pivotal moment in human history, yet the details surrounding its discovery are shrouded in mystery. There remains no scholarly consensus on key questions such as where, how and by whom this technology ...
Lee R. Alacoque +2 more
doaj +1 more source
Planning, art, and Post-WWII urban history in New York, Berlin, and Tokyo
, 2017 Thesis: Ph. D. in Architecture: History and Theory of Architecture, Massachusetts Institute of Technology, Department of Architecture, 2017.Cataloged from PDF version of thesis.
Schmidt, Sebastian, Ph. D. Massachusetts Institute of Technology
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Swinburne College of Technology Faculty of Art handbook 1973
, 1973 Swinburne College of Technology Faculty of Art handbook including general information, course descriptions and subject details for the year ...
Swinburne College of Technology
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
L’impératif de la sobriété numérique : enjeux et définitions
Humanités NumériquesThis article outlines the history of digital technology, identifying the main trends at work and documenting their ecological implications. It then draws up an overview of the main regulations at work, and concludes that they have more to do with ...
Fabrice Flipo
doaj +1 more source
Ethnography of reproductive travel from Turkey to Northern Cyprus
, 2019 Thesis: Ph. D. in History, Anthropology, and Science, Technology and Society (HASTS), Massachusetts Institute of Technology, Program in Science, Technology and Society, 2019Cataloged from PDF version of thesis.Includes bibliographical references (pages ...
Mutlu, Burcu,Ph. D.Massachusetts Institute of Technology.
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source