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, 2007 Some of the next articles are maybe not open access.
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Hit discovery and hit-to-lead approaches
Drug Discovery Today, 2006Hit discovery technologies range from traditional high-throughput screening to affinity selection of large libraries, fragment-based techniques and computer-aided de novo design, many of which have been extensively reviewed. Development of quality leads using hit confirmation and hit-to-lead approaches present their own challenges, depending on the hit
György M, Keseru, Gergely M, Makara
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Double hit, triple hit—look for it
Blood, 2013![Figure][1] A 68-year-old patient was admitted to our hospital with a short history of constipation and dyspnea. Cytology of the pleural effusion revealed large blastoid B cells. Positron emission tomography/computed tomography scan showed extensive fluorodeoxyglucose activity.
Rudolf, Benz, Joelle, Tchinda
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Ploughshares, 2011
This 40th anniversary issue edited by best-selling novelist Alice Hoffman (The Dovekeepers, Practical Magic) features new work from Ursula K. Le Guin, Marge Piercy, Jennifer Haigh, Ann Hood, and Wally Lamb; an interview with Elizabeth Bishop from the archives; and a story from Ploughshares ' first Emerging Fiction Writer's Award winner Thomas Lee.
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This 40th anniversary issue edited by best-selling novelist Alice Hoffman (The Dovekeepers, Practical Magic) features new work from Ursula K. Le Guin, Marge Piercy, Jennifer Haigh, Ann Hood, and Wally Lamb; an interview with Elizabeth Bishop from the archives; and a story from Ploughshares ' first Emerging Fiction Writer's Award winner Thomas Lee.
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Criminal Justice and Behavior, 2003
Within the study of intimate partner violence (IPV), controversy exists over whether perpetration and victimization of domestic violence is gender specific (gendered). Some researchers maintain no or few gender differences in IPV offending and victimization, particularly at less severe levels.
Heather C. Melton, Joanne Belknap
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Within the study of intimate partner violence (IPV), controversy exists over whether perpetration and victimization of domestic violence is gender specific (gendered). Some researchers maintain no or few gender differences in IPV offending and victimization, particularly at less severe levels.
Heather C. Melton, Joanne Belknap
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Hit-to-Lead: Hit Validation and Assessment
2018High-throughput screening assays have become nearly ubiquitous in the search for small compounds or peptides that can modulate biological processes for therapeutic purposes. While many assays have become quite robust, with well-established protocols, the subsequent steps of validating the hits and choosing the best ones to take forward into leads for ...
Kirk E, Hevener +5 more
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