Results 241 to 250 of about 2,028,215 (291)

Hit discovery and hit-to-lead approaches

Drug Discovery Today, 2006
Hit discovery technologies range from traditional high-throughput screening to affinity selection of large libraries, fragment-based techniques and computer-aided de novo design, many of which have been extensively reviewed. Development of quality leads using hit confirmation and hit-to-lead approaches present their own challenges, depending on the hit
György M, Keseru, Gergely M, Makara
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Double hit, triple hit—look for it

Blood, 2013
![Figure][1] A 68-year-old patient was admitted to our hospital with a short history of constipation and dyspnea. Cytology of the pleural effusion revealed large blastoid B cells. Positron emission tomography/computed tomography scan showed extensive fluorodeoxyglucose activity.
Rudolf, Benz, Joelle, Tchinda
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Hit-to-Lead: Hit Validation and Assessment

2018
High-throughput screening assays have become nearly ubiquitous in the search for small compounds or peptides that can modulate biological processes for therapeutic purposes. While many assays have become quite robust, with well-established protocols, the subsequent steps of validating the hits and choosing the best ones to take forward into leads for ...
Kirk E, Hevener, Russell, Pesavento, JinHong, Ren, Hyun, Lee, Kiira, Ratia, Michael E, Johnson   +5 more
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Hitting and Getting Hit

Ploughshares, 2011
This 40th anniversary issue edited by best-selling novelist Alice Hoffman (The Dovekeepers, Practical Magic) features new work from Ursula K. Le Guin, Marge Piercy, Jennifer Haigh, Ann Hood, and Wally Lamb; an interview with Elizabeth Bishop from the archives; and a story from Ploughshares ' first Emerging Fiction Writer's Award winner Thomas Lee.
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Hitting the buffers

Nature Chemistry, 2021
Bruce C. Gibb reminds us that buffers are not necessarily innocent bystanders and that they can bind to biomacromolecules too.
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Hit and run

ACM SIGGRAPH 2009 Computer Animation Festival, 2009
Deep in their secret hideouts, two heroes receive an urgent call: disaster has struck! When evil is on the loose, saving the day is what these two defenders of virtue do best, until they inadvertently get into a fender bender with each other. Now Deconstructor and the Knockout, two of the world's greatest costumed crime fighters, are stuck bickering ...
Alex Marino, Greg Peltz
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But, Gertrude, I Beg to Differ, a Hit Is Not a Hit Is Not a Hit

Violence Against Women, 2002
Not everyone who uses violence against his or her intimate partner is a batterer. It is essential to conduct a full, contextualized analysis of any violent relationship to determine if there is battering in the relationship and, if so, who is the batterer.
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