Results 141 to 150 of about 658,368 (320)
Identifying Interaction Sites in "Recalcitrant" Proteins: Predicted Protein and Rna Binding Sites in Rev Proteins of Hiv-1 and Eiav Agree with Experimental Data [PDF]
arXiv, 2005 Protein-protein and protein nucleic acid interactions are vitally important for a wide range of biological processes, including regulation of gene expression, protein synthesis, and replication and assembly of many viruses. We have developed machine learning approaches for predicting which amino acids of a protein participate in its interactions with ...
arxiv
Crystal structure of a complex of HIV‐1 protease with a dihydroxyethylene‐containing inhibitor: Comparisons with molecular modeling [PDF]
, 1992 Narmada Thanki +9 more
openalex +1 more source
Asian Journal of Organic Chemistry, EarlyView.The cascade Michael/intramolecular transamidation reactions of 3‐phenacylidene‐2‐indolinone derivatives bearing a trifluoromethyl group as a novel Michael acceptor with hydrazines yielded the corresponding pyrazolidin‐3‐one derivatives in good to high yields with excellent diastereoselectivity.
Ryo Tsuyusaki +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.What are the tasks of chemical process development in the pharmaceutical industry? What are trends and challenges? This Scientific Perspective written by members of the European pharmaceutical industry introduces key concepts of drug development and key drivers for the future of chemical process development.
Joachim Krueger +12 more
wiley +2 more sources
Clinical symptoms associated with seroconversion for HIV-1 among misusers of intravenous drugs: comparison with homosexual seroconverters and infected and non-infected intravenous drug misusers. [PDF]
, 1993 Gerard H.C. Mientjes +4 more
openalex +1 more source
New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain
Angewandte Chemie, EarlyView.We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song +8 more
wiley +2 more sources
Angewandte Chemie, EarlyView.This study designs an anchor peptide‐based immobilization strategy to expand the application of Pickering emulsion to glycosyltransferases (GTs) for the first time, addressing low conversion challenge in aqueous solutions. The glycosylation Pickering emulsion achieved more than 90% conversion of natural product glycosides with high recyclability ...
Peng Zhang +5 more
wiley +2 more sources
Doravirine and Its Potential in the Treatment of HIV: An Evidence-Based Review of the Emerging Data
HIV/AIDS: Research and Palliative Care, 2020 Alexander E Rock,1 Jeremy Lerner,2 Melissa E Badowski1 1University of Illinois, College of Pharmacy, Department of Pharmacy Practice, Section of Infectious Diseases Pharmacotherapy, Chicago, IL 60612, USA; 2University of Illinois, College of Pharmacy ...
Rock AE, Lerner J, Badowski ME
doaj
Australian Journal of Social Issues, EarlyView.ABSTRACT This qualitative study aimed to understand how migration experiences shape wellbeing and quality of life (QoL) for Asian‐born men who have sex with men (MSM) who are living with HIV in Australia, and to identify relevant support needs. Drawing from intersectionality theory, this paper reports findings from semi‐structured interviews with Asian‐
Thomas Norman +9 more
wiley +1 more source