Results 121 to 130 of about 22,163,553 (318)

MDR1 genetic polymorphism does not modify cell permissiveness to HIV-1 or disease progression before treatment [PDF]

, 2004
Nonphysiological overexpression of the ABC transporter Pglycoprotein (P-gp), which is encoded by MDR1, has been associated with reduced susceptibility to human immunodeficiency virus (HIV) type 1 infection in vitro.
Telenti, A, Suarez, C, Egger, Matthias, Bleiber, G, May, MT, Martinez, R, Egger, M., Telenti, Amalio, Marzolini, Catia, Martinez, Raquel, Telenti, A., Marzolini, C., Swiss HIV Cohort Study,, Marzolini, C, Bleiber, Gabriela, Suarez, C., May, Margaret, Bleiber, G., May, M., Martinez, R., Suarez, Carlos, Egger, M   +21 more
core   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Analysis of genetic polymorphisms and drug resistance mutations in the NS5 region of HCV genome (Flasuviricetes: Amarillovirales: Flaviviridae: Hepacivirus C) in samples obtained in 2022–2023 from HIV-infected treatment-naive residents of Altai Krai

Вопросы вирусологии
Introduction. Altai Krai is a region with an unfavorable situation of HIV-1 and HCV infection, as well as HIV-1 and HCV coinfection. Due to this, it is necessary to study the HCV genetic variants and their drug resistance (DR) to direct-acting antivirals
Ilya A. Lapovok, Arina V. Syrkina, Alina A. Kirichenko, Anastasia V. Shlykova, Natalya V. Lukyanenko, Tatyana V. Safyanova, Arina E. Safronova, Valery V. Shevchenko, Dmitry E. Kireev   +8 more
doaj   +1 more source

Characterisation of llama antibody fragments able to act as HIV-1 entry inhibitors [PDF]

, 2009
Human immunodeficiency virus type 1 (HIV-1) entry into cells is mediated by the functional envelope spike, which consists of trimers of gp120 bound to gp41.
Forsman, A M M, Forsman, A.M.M.
core  

HIV-1 tropism [PDF]

Protein & Cell, 2010
Aikichi, Iwamoto, Noriaki, Hosoya, Ai, Kawana-Tachikawa   +2 more
openaire   +2 more sources

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Prevalence of HIV Transmitted Drug Resistance in Nanjing from 2018 to 2021

Infection and Drug Resistance, 2023
Yifan Su,1 Mingxue Qi,1 Mingli Zhong,2 Nawei Yu,1 Chen Chen,1 Zi Ye,1 Cong Cheng,1 Zhiliang Hu,1 Hongying Zhang,3 Hongxia Wei1 1Department of Infectious Disease, The Second Hospital of Nanjing Affiliated to Nanjing University of Chinese Medicine, Nanjing,
Su Y, Qi M, Zhong M, Yu N, Chen C, Ye Z, Cheng C, Hu Z, Zhang H, Wei H   +9 more
doaj  

Enhancement of HIV-1 proteinase activity by HIV-1 reverse transcriptase

Virology, 1995
HIV-1 reverse transcriptase (RT) was found to increase the activity of HIV-1 proteinase in vitro and in eukaryotic cells. The effect of RT on proteinase activity was dose-dependent and independent of pH or salt concentration. The cleavage of sequences corresponding to all the naturally occurring cleavage sites that could be tested in vitro was enhanced.
Goobar-Larsson, Laura, Mattias Luukkonen, B.G., Unge, Torsten, Schwartz, Stefan, Utter, Göran, Strandberg, Bror, Öberg, Bo   +6 more
openaire   +2 more sources

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Rab7A Is Required for Efficient Production of Infectious HIV-1 [PDF]

, 2011
Retroviruses take advantage of cellular trafficking machineries to assemble and release new infectious particles. Rab proteins regulate specific steps in intracellular membrane trafficking by recruiting tethering, docking and fusion factors, as well as ...
Pelchen–Matthews Annegret, Delphine Delcroix-Genête, Annegret Pelchen–Matthews, Caillet, M, Pelchen-Matthews, A, Marsh Mark, Berlioz-Torrent, Clarisse, Camus Grégory, Annegret Pelchen-Matthews, Berlioz-Torrent Clarisse, Janvier, K, Janvier Katy, Delcroix-Genête, Delphine, Caillet Marina, Katy Janvier, Marsh, M, Caillet, Marina, Clarisse Berlioz-Torrent, Camus, Gregory, Mark Marsh, Berlioz-Torrent, C, Marina Caillet, Marina Caillet, Pelchen-Matthews, Annegret, Marsh, Mark, Camus, G, Grégory Camus, Delcroix-Genete, D, Janvier, Katy, Delcroix-Genête Delphine   +29 more
core   +1 more source