Results 111 to 120 of about 31,026,669 (309)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

The relationship between HIV seroconversion illness, HIV test interval and time to AIDS in a seroconverter cohort. [PDF]

, 2003
Seroconversion illness is known to be associated with more rapid HIV disease progression. However, symptoms are often subjective and prone to recall bias.
UK Register of HIV Seroconverters, UK, Gillett, J, Tyrer, F, Porter, K, Walker, AS   +4 more
core  

Early Therapy in HIV-1-Infected Children: Effect on HIV-1 Dynamics and HIV-1-Specific Immune Response

Antiviral Therapy, 2008
Background Perinatal HIV-1 infection is acquired in the milieu of a developing immune system, leading to high levels of uncontrolled viral replication. Few data have been reported that address the viral dynamics and immunological response in infants who initiated aggressive antiretroviral therapy (ART) shortly ...
M. Zanchetta, A. Anselmi, D. Vendrame, O. Rampon, C. Giaquinto, A. Mazza, ACCAPEZZATO, DANIELE, BARNABA, Vincenzo, A. De Rossi   +8 more
openaire   +4 more sources

Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency

Frontiers in Cellular and Infection Microbiology, 2023
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +1 more source

Evaluation of anti-HIV-1 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus type 1) activity of 6HP and 3TC in vitro using MT-4 cell line variants with different replicative activity

Вопросы вирусологии
Introduction. Chemotherapy of HIV infection remains the only means of treating the disease. The process of development new and improving previously developed drugs is therefore considered a priority.
Lyudmila B. Kalnina, Lyudmila M. Selimova, Dmitry N. Nosik   +2 more
doaj   +1 more source

Lipopeptides as dimerization inhibitors of HIV-1 protease [PDF]

, 1999
In AIDS therapy, attempts have been made to inhibit the virus-encoded enzymes, e.g, HIV-1 protease, using active site-directed inhibitors. This approach is questionable, however, due to virus mutations and the high toxicity of the drugs, An alternative ...
Schramm, W., Schramm, H. J., Büttner, J., de Rosny, E., Dick, A., Reboud-Ravaux, M.   +5 more
core   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design [PDF]

, 2014
Includes bibliographical references.Inducing broadly neutralizing antibodies targeting the HIV-1 envelope is thought to be crucial for developing an effective vaccine.
Jacob, Rajesh Abraham
core   +1 more source

Corrigendum: Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency

Frontiers in Cellular and Infection Microbiology, 2023
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +1 more source

The molecular mechanism of HIV-1 transcriptional elongation regulating latent infection

Guangxi Yike Daxue xuebao
Human immunodeficiency virus type 1 (HIV-1) is the main causative agent of acquired immunodeficiency syndrome (AIDS), and there is currently no effective cure. Although the existing antiretroviral therapy (ART) can effectively suppress virus replication,
HU Shujing, DENG Kai
doaj   +1 more source