Results 101 to 110 of about 22,163,553 (318)

Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses

, 2010
Since HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in HIV-1
McKinnon, E., Rebecca Laird, Chopra, A., John, M., Simon Mallal, Almeida, C.M., Keane, N.M., Abha Chopra, David Heckerman, Heckerman, D., Imran Ahmad, Coral-Ann M. Almeida, Elizabeth McKinnon, Carl Kadie, Roberts, S.G., Mina John, Kadie, C., Niamh M. Keane, Laird, R., Steven G. Roberts, Ahmad, I., Mallal, S.   +21 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

EpiMolBio: A novel user-friendly bioinformatic program for genetic variability analysis

Computational and Structural Biotechnology Journal
Purpose: Genetic sequence analysis has become essential in many fields of medicine, biology, and epidemiology. However, the currently available tools can pose a challenge for users without advanced computational skills.
Roberto Reinosa, Paloma Troyano-Hernáez, Ana Valadés-Alcaraz, África Holguín   +3 more
doaj   +1 more source

Generating Vectors for the Lattice Structures of Tubular and Conical Viral Capsids

Computational and Mathematical Biophysics, 2014
Retrovirus capsid is a fullerene-like lattice consisting of capsid protein hexamers and pentamers. Mathematical models for the lattice structure help understand the underlying biological mechanisms in the formation of viral capsids.
Sadre-Marandi Farrah, Liu Jiangguo, Tavener Simon, Chen Chaoping   +3 more
doaj   +1 more source

Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj

, 2009
Background: Human primary monocytes are refractory to infection with the human immunodeficiency virus 1 (HIV-1) or transduction with HIV-1-derived vectors.
Kaiser, Julia, Schüle Silke, Wolfrum, Nina, Heidmeier Sabine, Sylvia Panitz, Julia K Kaiser, Panitz Sylvia, Klaus Cichutek, Silke Schüle, Heidmeier, Sabine, Kaiser Julia K., Schweizer, Matthias, Cichutek Klaus, Schüle, Silke, Kloke, Björn-Philipp, Matthias Schweizer, Wolfrum Nina, Panitz, Sylvia, Sabine Heidmeier, Cichutek, Klaus, Nina Wolfrum, Kloke Björn-Philipp, Schweizer Matthias, Björn-Philipp Kloke   +23 more
core   +1 more source

Cervicovaginal HIV-1 shedding in women taking antiretroviral therapy in Burkina Faso: a longitudinal study. [PDF]

, 2013
BACKGROUND: Antiretroviral therapy (ART) reduces transmission of HIV-1. However, genital HIV-1 can be detected in patients on ART. We analyzed factors associated with genital HIV-1 shedding among high-risk women on ART in Burkina Faso.
Kania, Dramane, Segondy, Michel, Mabey, David, Meda, Nicolas, Weiss, Helen A, Vickerman, Peter, van de Perre, Philippe, Nagot, Nicolas, Low, Andrea, Mayaud, Philippe, ?, ?, Low, Andrea J, Pillay, Deenan, Konate, Issouf, Yerelon Study Group, Weiss, Helen, Pillay, Deenan,   +16 more
core   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Hybrid Spreading Mechanisms and T Cell Activation Shape the Dynamics of HIV-1 Infection

, 2015
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts.
Pellegrino, P, Groppelli, E, Elisabetta Groppelli (258517), Jolly, C, Ian Williams (208301), Changwang Zhang (716808), Persephone Borrow, Borrow, P, Chain, BM, Benjamin M Chain, Zhou, S, Zhou, Shi, Groppelli, Elisabetta, Persephone Borrow (194557), Ian Williams, Zhang, Changwang, Pellegrino, Pierre, Changwang Zhang, Jolly, Clare, Elisabetta Groppelli, Shi Zhou, Clare Jolly (207781), Pierre Pellegrino (208300), Benjamin M. Chain (154754), Pierre Pellegrino, Williams, Ian, Borrow, Persephone, Shi Zhou (452014), Zhang, C, Chain, Benjamin M., Williams, I, Clare Jolly   +31 more
core   +1 more source

Early Therapy in HIV-1-Infected Children: Effect on HIV-1 Dynamics and HIV-1-Specific Immune Response

Antiviral Therapy, 2008
Background Perinatal HIV-1 infection is acquired in the milieu of a developing immune system, leading to high levels of uncontrolled viral replication. Few data have been reported that address the viral dynamics and immunological response in infants who initiated aggressive antiretroviral therapy (ART) shortly ...
M. Zanchetta, A. Anselmi, D. Vendrame, O. Rampon, C. Giaquinto, A. Mazza, ACCAPEZZATO, DANIELE, BARNABA, Vincenzo, A. De Rossi   +8 more
openaire   +4 more sources