Results 101 to 110 of about 22,166,132 (318)

Mapping Transmission Dynamics and Drug Resistance Surveillance in the Cyprus HIV-1 Epidemic (2017–2021)

Viruses
The human immunodeficiency virus type 1 (HIV-1) epidemic has been a major public health threat on a global scale since the early 1980s. Despite the introduction of combination antiretroviral therapy (cART), the incidence of new HIV-1 infections continues
Cicek Topcu, Bram Vrancken, Johana Hezka Rodosthenous, David van de Vijver, Georgios Siakallis, Philippe Lemey, Leondios G. Kostrikis   +6 more
doaj   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Declining HIV-1 Prevalence and Incidence among Police Officers - A potential Cohort for HIV Vaccine Trials, in Dar es Salaam, Tanzania. [PDF]

, 2013
A safe effective and affordable HIV vaccine is the most cost effective way to prevent HIV infection worldwide. Current studies of HIV prevalence and incidence are needed to determine potentially suitable cohorts for vaccine studies.
Munseri, P. J., Bakari, M, Bakari, Muhammad, Eric Sandstrom, Mohamed Janabi, Janabi, M, Aris, E, Hejdeman, B,, Patricia J Munseri, Hejdeman, Bo, Hejdeman, B., Muhammad Bakari, Sandstrom, E, Sandstrom, E., Said Aboud, Bo Hejdeman, Aboud, Said, Munseri, Patricia J, Eric Aris, Aboud, S., Aris, E., Janabi, Mohamed, Aboud, S, Aris, Eric, Sandstrom, Eric, Janabi, M., Bakari, M., Munseri, PJ   +27 more
core   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Labs During Methotrexate Therapy

Arthritis Care &Research, Accepted Article.
Objective To evaluate whether extending the American College of Rheumatology (ACR)–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

Resurgence of HIV infection among men who have sex with men in Switzerland : mathematical modelling study [PDF]

, 2012
New HIV infections in men who have sex with men (MSM) have increased in Switzerland since 2000 despite combination antiretroviral therapy (cART). The objectives of this mathematical modelling study were: to describe the dynamics of the HIV epidemic in ...
Steven Derendinger (134735), Swiss HIV, Cohort Study, Glass, T. R., Fraser, C., Steven Derendinger, Christophe Fraser (7754), Vernazza, P., Frank de Wolf, Ard van Sighem (134719), Beatriz Vidondo (134721), Martin Gebhardt, Swiss HIV Cohort Study, Beatriz Vidondo, de Wolf Frank, Derendinger Steven, van Sighem, Ard, Jeannin André, Vernazza Pietro, Heiner C Bucher, Low, N., Martin Gebhardt (134732), Nicola Low (62560), Vidondo, B., Derendinger, Steven, Pietro Vernazza (82546), De Wolf, F., Bucher, Heiner C., Bezemer, D., Tracy R. Glass (134725), Bezemer, Daniela, Jeannin, André, Gebhardt, Martin, Bucher Heiner C., Tracy R Glass, de Wolf, Frank, Vidondo, Beatriz, Heiner C. Bucher (134728), Christophe Fraser, Jeannin, A., Daniela Bezemer, Gebhardt Martin, Bezemer Daniela, Bucher, H. C., Glass, Tracy R., Pietro Vernazza, Low Nicola, van Sighem Ard, André Jeannin, Daniela Bezemer (134739), Nicola Low, Glass Tracy R., Fraser, Christophe, Derendinger, S., Vidondo Beatriz, Ard van Sighem, Gebhardt, M., André Jeannin (134737), Frank de Wolf (89583), Fraser Christophe, Vernazza, Pietro, Low, Nicola, Van Sighem, A.   +61 more
core   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants. [PDF]

, 2006
BACKGROUND: Heterosexual intercourse remains the major route of HIV-1 transmission worldwide, with almost 5 million new infections occurring each year.
Wallace, GS, Mesquita Pedro MM, Fletcher, PS, Fletcher Patricia S, Patricia S Fletcher, Wallace Gregory S, Mesquita, PM, Pedro MM Mesquita, Robin J Shattock, Shattock Robin J, Gregory S Wallace, Shattock, RJ   +11 more
core   +1 more source

Genetic Diversity and Acquired Drug Resistance Mutations Detected by Deep Sequencing in Virologic Failures among Antiretroviral Treatment Experienced Human Immunodeficiency Virus-1 Patients in a Pastoralist Region of Ethiopia

Infection and Drug Resistance, 2021
Erdaw Tachbele,1,2 Samuel Kyobe,3 Fred Ashaba Katabazi,3 Edgar Kigozi,3 Savannah Mwesigwa,3 Moses Joloba,3 Alebachew Messele,1 Wondwossen Amogne,2 Mengistu Legesse,1 Rembert Pieper,4 Gobena Ameni1 1Aklilu Lemma Institute of Pathobiology, Addis Ababa ...
Tachbele E, Kyobe S, Katabazi FA, Kigozi E, Mwesigwa S, Joloba M, Messele A, Amogne W, Legesse M, Pieper R, Ameni G   +10 more
doaj  

Microneedles Mediated Delivery of Nanodiamonds for Quantum Sensing of Free Radicals in Skin Tissue

Advanced Materials Technologies, EarlyView.
Fluorescent nanodiamonds are nanoscale sensors capable of monitoring cellular stress responses. However, to function effectively, they must be delivered into cells or tissues. Here, we demonstrate their application in the skin by developing a dissolvable microneedle platform that dissolves after skin insertion, enabling the delivery of nanodiamonds ...
Siyu Fan, Maria Carmona Lobita, Thea Vedelaar, Yue Zhang, Claudia Reyes‐San‐Martin, Tomás Bauleth‐Ramos, Gésinda Geertsema‐Doornbusch, Han Gao, Mohammad‐Ali Shahbazi, Hélder A. Santos, Romana Schirhagl   +10 more
wiley   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source