Results 81 to 90 of about 867,008 (306)

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Release of Soluble Ligands for the Activating NKG2D Receptor: One More Immune Evasion Strategy Evolved by HIV-1? [PDF]

, 2016
ncreasing lines of evidence indicate that NKG2D, an activating receptor of natural killer (NK) and CD8(+) T cells, plays an important role in immune responses against HIV-1. Through its ability to recognize a diverse array of ligands (NKG2DLs) induced by
Cerboni, Cristina, Doria, Margherita, Giuliani, Rica, Vassena, Lia   +3 more
core   +1 more source

HIV-1 Protease Inhibitors [PDF]

Clinical Infectious Diseases, 2000
Treatment of human immunodeficiency virus type 1 (HIV-1) infection with regimens that include protease inhibitors (PIs) has contributed to marked improvements in HIV-related disease progression and mortality. Five PIs are approved by the US Food and Drug Administration and have potent activity in vitro.
openaire   +2 more sources

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Characteristics, Immunological Response & Treatment Outcomes of HIV-2 Compared with HIV-1 & Dual Infections (HIV 1/2) in Mumbai [PDF]

, 2010
Information available on HIV-2 and dual infection (HIV-1/2) is limited. This study was carried out among HIV positive individuals in an urban referral clinic in Khar, Mumbai, India, to report on relative proportions of HIV-1, HIV-2 and HIV-1/2 and ...
Alaka, Deshpande, Bhanumati, Varghese, Chiara, Montaldo, Harries, A D, Homa, Mansoor, Ladomirska, Joanna, Manzi, M, Rony, Zachariah, Wilson, N   +8 more
core   +1 more source

Assisted evolution enables HIV-1 to overcome a high trim5α-imposed genetic barrier to rhesus macaque tropism [PDF]

, 2013
Diversification of antiretroviral factors during host evolution has erected formidable barriers to cross-species retrovirus transmission. This phenomenon likely protects humans from infection by many modern retroviruses, but it has also impaired the ...
A Kuroishi, A Lassaux, A Reymond, AM Sheehy, AM Sheehy, B Jia, B Pacheco, B Song, BK Ganser-Pornillos, C Aberham, CA Virgen, CA Virgen, CH Liao, D Blanco-Melo, D Perez-Caballero, D Perez-Caballero, E Battivelli, EE Nakayama, F Zhang, F Zhang, G Brennan, GB Mortuza, GJ Towers, H Yang, HL Wiegand, Jeremy Luban, JW Bainbridge, K Hrecka, KR McCarthy, L Yin, M Pizzato, M Stremlau, M Stremlau, M Stremlau, M Stremlau, M Veillette, MJ Perron, MJ Perron, MR Auerbach, MW McNatt, MW Yap, MW Yap, N Van Damme, O Pornillos, Paul D. Bieniasz, R Mariani, RM Newman, S Cowan, S Ohkura, S Ohkura, S Sebastian, Sam J. Wilson, SB Kutluay, Sebla B. Kutluay, SJ Neil, SJ Rihn, SJ Wilson, SJ Wilson, SJ Wilson, SL Sawyer, Steven J. Soll, SY Lim, T Hatziioannou, T Hatziioannou, T Hatziioannou, T Hatziioannou, T Hatziioannou, Theodora Hatziioannou, V Zennou, X Yu, Y Soneoka, YH Zheng, YJ Zhang, Z Ambrose, Z Keckesova, Z Kratovac   +75 more
core   +3 more sources

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Lens-epithelium-derived growth-factor (LEDGF/p75)-binding site on HIV-1 integrase (IN), is an attractive target for antiviral chemotherapy. Small-molecule compounds binding to this site are referred as LEDGF-IN inhibitors (LEDGINs).
Da-Wei Zhang, Hao-Li Yan, Xiao-Shuang Xu, Lei Xu, Zhi-Hui Yin, Shan Chang, Heng Luo   +6 more
doaj   +1 more source

altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers. [PDF]

, 2018
The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule.
Genebat González, Miguel, Leal Noval, Manuel, Ruiz-Mateos Carmona, Ezequiel, Tarancon Diez, Laura   +3 more
core   +1 more source

Mapping Transmission Dynamics and Drug Resistance Surveillance in the Cyprus HIV-1 Epidemic (2017–2021)

Viruses
The human immunodeficiency virus type 1 (HIV-1) epidemic has been a major public health threat on a global scale since the early 1980s. Despite the introduction of combination antiretroviral therapy (cART), the incidence of new HIV-1 infections continues
Cicek Topcu, Bram Vrancken, Johana Hezka Rodosthenous, David van de Vijver, Georgios Siakallis, Philippe Lemey, Leondios G. Kostrikis   +6 more
doaj   +1 more source