Results 61 to 70 of about 867,008 (306)
Emerging Microbes and Infections, 2022 HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune ...
Jing Wen +12 more
doaj +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection [PDF]
, 2015 HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts.
Borrow, Persephone +7 more
core +4 more sources
BMJ OpenObjectives To examine the global and regional trends in disparities of high systolic blood pressure (HSBP) burden between 1990 and 2021 by age, sex, sociodemographic index and health systems’ performance.Design Systematic analysis.Setting Global ...
Hamid Sharifi +4 more
doaj +1 more source
New England Journal of Medicine, 2005 To the Editor: Dual infection with different strains of HIV type 1 (HIV-1) is reported with increasing frequency, attributed mostly to coinfection at the time of the primary infection. However, some patients were superinfected with a second virus after the original seroconversion,1 which generally accelerated disease progression.2 We encountered a case
van der Kuyl, A.C. +8 more
openaire +3 more sources
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
cAMP Signaling Enhances HIV-1 Long Terminal Repeat (LTR)-directed Transcription and Viral Replication in Bone Marrow Progenitor Cells. [PDF]
, 2017 CD34+ hematopoietic progenitor cells have been shown to be susceptible to HIV-1 infection, possibly due to a low-level expression of CXCR4, a coreceptor for HIV-1 entry.
Banerjee, Anupam +5 more
core +3 more sources
Chinese Medical Journal. Background:. Total human immunodeficiency virus (HIV) DNA and integrated HIV DNA are widely used markers of HIV persistence. Droplet digital polymerase chain reaction (ddPCR) can be used for absolute quantification without needing a standard curve ...
Lin Yuan +16 more
doaj +1 more source
Molecules, 2020 Despite great efforts have been made in the prevention and therapy of human immunodeficiency virus (HIV-1) infection, however the difficulty to eradicate latent viral reservoirs together with the emergence of multi-drug-resistant strains require the ...
Jenny Desantis +10 more
doaj +1 more source
Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides
Beilstein Journal of Organic Chemistry, 2021 Lipid nanoparticles (LNPs) constitute a facile and scalable approach for delivery of payloads to human cells. LNPs are relatively immunologically inert and can be produced in a cost effective and scalable manner.
Roslyn M. Ray +7 more
doaj +1 more source