Results 61 to 70 of about 31,026,669 (309)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The Use of Complementary Alternative Medicine in HIV-infected Patients during COVID-19 Pandemic: Its Related Factors and Drug Interactions with Antiretroviral Therapy

Acta Medica Indonesiana, 2022
Background: The use of complementary and alternative medicine (CAM) is widespread among patients with chronic disease despite lack of supporting evidence for most CAM types.
Evy Yunihastuti, Teguh Harjono Karjadi, Nafrialdi Nafrialdi, Indah Mediana, Salma Sundari, Andrian Wiraguna, Aljira Fitya Hapsari, Amalia Irsha Adhari, Aulia N. S. Putri Khumaini, Tiara Kumala Putri   +9 more
doaj  

Cost-effectiveness of voluntary HIV-1 counseling and testing in reducing sexual transmission of HIV-1 in Kenya and Tanzania. [PDF]

, 2000
Background Access to HIV-1 voluntary counseling and testing (VCT) is severely limited in less-developed countries. We undertook a multisite trial of HIV-1 VCT to assess its impact, cost, and cost-effectiveness in less-developed country settings.\ud ...
Sangiwa , G, Balmer, D, Sweat , M, Furlonge , C, Coates , T, Kamenga , C, Gregorich , S, Grinstead, O   +7 more
core  

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

A Canadian Survey of Research on HIV-1 Latency—Where Are We Now and Where Are We Heading?

Viruses
Worldwide, almost 40 million people are currently living with HIV-1. The implementation of cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently infected cells.
Ana Luiza Abdalla, Gabriel Guajardo-Contreras, Andrew J. Mouland   +2 more
doaj   +1 more source

Breast Milk from Tanzanian Women has Divergent Effects on Cell-Free and Cell-Associated HIV-1 Infection in Vitro. [PDF]

, 2012
Transmission of HIV-1 during breastfeeding is a significant source of new pediatric infections in sub-Saharan Africa. Breast milk from HIV-positive mothers contains both cell-free and cell-associated virus; however, the impact of breast milk on HIV-1 ...
Ruth I Connor, Alexandra L Howell, Molly L Housman, Lee, F.V, Housman, M.L., Zain-Ul-Abideen Muhammad, Frederick V Lee, Zain-Ul-Abideen, M., Connor, R.I, Connor Ruth I., Zain-Ul-Abideen, Muhammad, Lyimo, M.A., Howell, Alexandra L, Lyimo, Magdalena A, Magdalena A Lyimo, Howell Alexandra L., Housman, Molly L, Mosi, M.N, Muhammad Zain-Ul-Abideen, Howell, A.L, Lee, Frederick V, Mosi, Matilda Ngarina, Matilda Ngarina Mosi, Connor, Ruth I, Lyimo Magdalena A., Housman Molly L., Mosi Matilda Ngarina, Lee Frederick V.   +27 more
core   +2 more sources

A Neuronal and Neuroanatomical Correlate of HIV-1 Encephalopathy Relative to HIV-1 Encephalitis in HIV-1-infected Children [PDF]

Journal of Neuropathology and Experimental Neurology, 1997
Progressive central nervous system dysfunction analogous to the AIDS dementia complex (ADC) seen in adults (HIV-1-associated progressive encephalopathy or HIV-1 encephalopathy) commonly occurs in HIV-1-infected children. The cause appears to be directly or indirectly related to HIV-1, rather than to other opportunistic pathogens. The exact mechanism(s)
A, da Cunha, M, Mintz, L E, Eiden, L R, Sharer   +3 more
openaire   +2 more sources

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Second European Round Table on the Future Management of HIV

Journal of Virus Eradication, 2015
The Second European Round Table on the Future Management of HIV took place in Barcelona, 10–11 October 2014 and focused on the HIV-1 reservoir, strategies for HIV cure and primary HIV infection (PHI).
Casper Rokx, Douglas D. Richman, Michaela Müller-Trutwin, Guido Silvestri, Jan Lunzen, van, Saye Khoo, Mathias Lichterfeld, Marcus Altfeld, Carlo Federico Perno, Peter W. Hunt, Paddy Mallon, Jürgen K. Rockstroh, Anton L. Pozniak, Bonaventura Clotet, Charles A.B. Boucher   +14 more
doaj   +1 more source

Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4+ T cells

Emerging Microbes and Infections, 2022
HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune ...
Jing Wen, Xin Li, Qing-Xia Zhao, Xiao-Fan Yang, Meng-Li Wu, Qihong Yan, Junbiao Chang, Haikun Wang, Xia Jin, Xiao Su, Kai Deng, Ling Chen, Jian-Hua Wang   +12 more
doaj   +1 more source