Results 61 to 70 of about 22,163,553 (318)

HIV-1 detection in the olfactory mucosa of HIV-1-infected participants

AIDS, 2019
HIV infection chronically affects the central nervous system (CNS). Olfactory mucosa is a unique site in the respiratory tract that is directly connected to the CNS; thus we wanted to evaluate olfactory mucosa as a surrogate of CNS sampling.We conducted a preliminary study examining HIV populations and susceptible cells in the olfactory mucosa ...
Bertero, Luca, Joseph, Sarah Beth, Trunfio, Mattia, Allice, Tiziano, Catera, Sebastiano, Imperiale, Daniele, Cassoni, Paola, Kincer, Laura Pesci, Pirriatore, Veronica, Ghisetti, Valeria, Amasio, Enrica, Zanusso, Gianluigi, Bonora, Stefano, Di Perri, Giovanni, Calcagno, Andrea   +14 more
openaire   +4 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Cost-effectiveness of voluntary HIV-1 counseling and testing in reducing sexual transmission of HIV-1 in Kenya and Tanzania. [PDF]

, 2000
Background Access to HIV-1 voluntary counseling and testing (VCT) is severely limited in less-developed countries. We undertook a multisite trial of HIV-1 VCT to assess its impact, cost, and cost-effectiveness in less-developed country settings.\ud ...
Sangiwa , G, Balmer, D, Sweat , M, Furlonge , C, Coates , T, Kamenga , C, Gregorich , S, Grinstead, O   +7 more
core  

The Role of HIV-1 DNA as an Additional Marker of HIV-1 Infection

Current HIV Research, 2009
After the infusion of HIV-1 virus into a host cell, RNA is reverse transcribed to dsDNA, which persists intracellular to the infected cell in a variety of forms. Numerous in-house assays have been developed for the quantification of the different cellular HIV-1 DNA forms; these implement conventional or real-time PCR methodology.
Beloukas, A., Paraskevis, D., Psichogiou, M., Hatzakis, A.   +3 more
openaire   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

The Use of Complementary Alternative Medicine in HIV-infected Patients during COVID-19 Pandemic: Its Related Factors and Drug Interactions with Antiretroviral Therapy

Acta Medica Indonesiana, 2022
Background: The use of complementary and alternative medicine (CAM) is widespread among patients with chronic disease despite lack of supporting evidence for most CAM types.
Evy Yunihastuti, Teguh Harjono Karjadi, Nafrialdi Nafrialdi, Indah Mediana, Salma Sundari, Andrian Wiraguna, Aljira Fitya Hapsari, Amalia Irsha Adhari, Aulia N. S. Putri Khumaini, Tiara Kumala Putri   +9 more
doaj  

National Multi-Sectoral Strategic Framework on HIV/AIDS 2003 - 2007 [PDF]

, 2003
Tanzania is facing a major threat to the survival of its people and the development chances of the nation from a concentrated and generalised HIV /AIDS epidemic. More than two Million people are estimated to be living with HIV /AIDS in 2002.
Tanzania Commission for HIV/AIDS, (TCAIDS)
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A Canadian Survey of Research on HIV-1 Latency—Where Are We Now and Where Are We Heading?

Viruses
Worldwide, almost 40 million people are currently living with HIV-1. The implementation of cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently infected cells.
Ana Luiza Abdalla, Gabriel Guajardo-Contreras, Andrew J. Mouland   +2 more
doaj   +1 more source