Results 91 to 100 of about 22,163,553 (318)

A Surface‐engineered Microfluidic Device for Antibody‐Mediated Negative Selection of High‐Quality Sperm for Assisted Reproduction

Advanced Functional Materials, EarlyView.
This study reports a microfluidic device with a functionalized surface utilizing a polyoxazoline coating and covalently immobilized gold nanoparticles and anti‐phosphatidylserine antibody. The device efficiently eliminates pre‐apoptotic and apoptotic spermatozoa and yields sperm with substantially improved quality and low DNA damage, offering a simple ...
Soraya Rasi Ghaemi, David J. Sharkey, Nicole O. McPherson, Markos Negash Alemie, Krasimir Vasilev, Sarah A. Robertson   +5 more
wiley   +1 more source

Enhanced Human Antigen‐Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells

Advanced Healthcare Materials, EarlyView.
We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham, Marlon de Gast, Liubov Babii, Sabine Kruijer, Theo M. Bestebroer, Mathilde Richard, Mathieu Claireaux, S. Marieke van Ham, Jelle de Wit, Cécile A. C. M. van Els, Anja ten Brinke, Marit J. van Gils   +11 more
wiley   +1 more source

Characteristics, Immunological Response & Treatment Outcomes of HIV-2 Compared with HIV-1 & Dual Infections (HIV 1/2) in Mumbai

, 2010
Information available on HIV-2 and dual infection (HIV-1/2) is limited. This study was carried out among HIV positive individuals in an urban referral clinic in Khar, Mumbai, India, to report on relative proportions of HIV-1, HIV-2 and HIV-1/2 and ...
Manzi, M, Harries, AD, Rony, Zachariah, Ladomirska, Joanna, Harries, A D, Wilson, N, Bhanumati, Varghese, Alaka, Deshpande, Homa, Mansoor, Chiara, Montaldo   +9 more
core  

Lipopeptides as dimerization inhibitors of HIV-1 protease [PDF]

, 1999
In AIDS therapy, attempts have been made to inhibit the virus-encoded enzymes, e.g, HIV-1 protease, using active site-directed inhibitors. This approach is questionable, however, due to virus mutations and the high toxicity of the drugs, An alternative ...
Schramm, W., Schramm, H. J., Büttner, J., de Rosny, E., Dick, A., Reboud-Ravaux, M.   +5 more
core   +1 more source

Declining HIV-1 Prevalence and Incidence among Police Officers - A potential Cohort for HIV Vaccine Trials, in Dar es Salaam, Tanzania. [PDF]

, 2013
A safe effective and affordable HIV vaccine is the most cost effective way to prevent HIV infection worldwide. Current studies of HIV prevalence and incidence are needed to determine potentially suitable cohorts for vaccine studies.
Munseri, P. J., Bakari, M, Bakari, Muhammad, Eric Sandstrom, Mohamed Janabi, Janabi, M, Aris, E, Hejdeman, B,, Patricia J Munseri, Hejdeman, Bo, Hejdeman, B., Muhammad Bakari, Sandstrom, E, Sandstrom, E., Said Aboud, Bo Hejdeman, Aboud, Said, Munseri, Patricia J, Eric Aris, Aboud, S., Aris, E., Janabi, Mohamed, Aboud, S, Aris, Eric, Sandstrom, Eric, Janabi, M., Bakari, M., Munseri, PJ   +27 more
core   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Genetic Adjuvants in Replicating Single-Cycle Adenovirus Vectors Amplify Systemic and Mucosal Immune Responses against HIV-1 Envelope

Vaccines, 2020
Most infections occur at mucosal surfaces. Providing a barrier of protection at these surfaces may be a useful strategy to combat the earliest events in infection when there are relatively few pathogens to address.
William E. Matchett, Goda Baddage Rakitha Malewana, Haley Mudrick, Michael J. Medlyn, Michael A. Barry   +4 more
doaj   +1 more source

Resurgence of HIV infection among men who have sex with men in Switzerland : mathematical modelling study [PDF]

, 2012
New HIV infections in men who have sex with men (MSM) have increased in Switzerland since 2000 despite combination antiretroviral therapy (cART). The objectives of this mathematical modelling study were: to describe the dynamics of the HIV epidemic in ...
Steven Derendinger (134735), Swiss HIV, Cohort Study, Glass, T. R., Fraser, C., Steven Derendinger, Christophe Fraser (7754), Vernazza, P., Frank de Wolf, Ard van Sighem (134719), Beatriz Vidondo (134721), Martin Gebhardt, Swiss HIV Cohort Study, Beatriz Vidondo, de Wolf Frank, Derendinger Steven, van Sighem, Ard, Jeannin André, Vernazza Pietro, Heiner C Bucher, Low, N., Martin Gebhardt (134732), Nicola Low (62560), Vidondo, B., Derendinger, Steven, Pietro Vernazza (82546), De Wolf, F., Bucher, Heiner C., Bezemer, D., Tracy R. Glass (134725), Bezemer, Daniela, Jeannin, André, Gebhardt, Martin, Bucher Heiner C., Tracy R Glass, de Wolf, Frank, Vidondo, Beatriz, Heiner C. Bucher (134728), Christophe Fraser, Jeannin, A., Daniela Bezemer, Gebhardt Martin, Bezemer Daniela, Bucher, H. C., Glass, Tracy R., Pietro Vernazza, Low Nicola, van Sighem Ard, André Jeannin, Daniela Bezemer (134739), Nicola Low, Glass Tracy R., Fraser, Christophe, Derendinger, S., Vidondo Beatriz, Ard van Sighem, Gebhardt, M., André Jeannin (134737), Frank de Wolf (89583), Fraser Christophe, Vernazza, Pietro, Low, Nicola, Van Sighem, A.   +61 more
core   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Genetic Diversity and Acquired Drug Resistance Mutations Detected by Deep Sequencing in Virologic Failures among Antiretroviral Treatment Experienced Human Immunodeficiency Virus-1 Patients in a Pastoralist Region of Ethiopia

Infection and Drug Resistance, 2021
Erdaw Tachbele,1,2 Samuel Kyobe,3 Fred Ashaba Katabazi,3 Edgar Kigozi,3 Savannah Mwesigwa,3 Moses Joloba,3 Alebachew Messele,1 Wondwossen Amogne,2 Mengistu Legesse,1 Rembert Pieper,4 Gobena Ameni1 1Aklilu Lemma Institute of Pathobiology, Addis Ababa ...
Tachbele E, Kyobe S, Katabazi FA, Kigozi E, Mwesigwa S, Joloba M, Messele A, Amogne W, Legesse M, Pieper R, Ameni G   +10 more
doaj