Results 51 to 60 of about 141,192 (322)

In-vivo mutation rates and fitness landscape of HIV-1

, 2016
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequencing data from longitudinal samples during untreated HIV-1 infection, we
Albert, Jan, Brodin, Johanna, Neher, Richard, Puller, Vadim, Zanini, Fabio   +4 more
core   +1 more source

Genetic diversity of Brazilian isolates of feline immunodeficiency virus [PDF]

, 2010
We isolated Feline immunodeficiency virus (FIV) from three adult domestic cats, originating from two open shelters in Brazil. Viruses were isolated from PBMC following co-cultivation with the feline T-lymphoblastoid cell line MYA-1.
A Duarte, A Reche Jr, AN Martins, B. J. Willett, BJ Willett, BJ Willett, BM Teixeira, Bruno Marques Teixeira, C Palmer, DL Lerner, DL Sodora, EA Weaver, EJ Verschoor, F Reggeti, FA Caxito, G Pancino, G Ryan, GA Dean, J. C. M. Cruz, J. K. P. Reis, JH Elder, JJ Hayward, JK Yamamoto, KH Siebelink, L. J. Richtzenhain, M Goodenow, M Torten, M. J. Hosie, M. K. Hagiwara, MA Rigby, MJ Hosie, MJ Hosie, MJ Hosie, MR Pecoraro, MT Kyaw-Tanner, MW Cho, N. Logan, NC Pedersen, P. E. Brandão, R Kann, RA Olmsted, RL Talbott, RV English, S Kakinuma, S Lombardi, T Hohdatsu, T Hohdatsu, T Miyazawa, TA Hall, W Huisman, WK Greene   +50 more
core   +1 more source

Proviral Quasispecies Diversity Is Not Associated With Virologic Breakthrough or CD4+ T Cell Loss in HIV-1 Elite Controllers

Frontiers in Microbiology, 2019
Elite controllers (EC) are able to control HIV-1 replication to extremely low levels (<50 HIV-1 RNA copies/mL) in the absence of antiretroviral therapy.
Suwellen S. D. de Azevedo, Fernanda H. Côrtes, Edson Delatorre, Marcelo Ribeiro-Alves, Brenda Hoagland, Beatriz Grinsztejn, Valdilea G. Veloso, Mariza G. Morgado, Gonzalo Bello   +8 more
doaj   +1 more source

Understanding the mechanisms driving the spread of subtype C HIV-1

EBioMedicine, 2020
Human immunodeficiency virus type 1 (HIV-1) subtype C (C-HIV) is the most prevalent form of HIV-1 globally, accounting for approximately 50% of infections worldwide. C-HIV is the predominant and near-exclusive subtype in the low resource regions of India
Matthew J. Gartner, Michael Roche, Melissa J. Churchill, Paul R. Gorry, Jacqueline K. Flynn   +4 more
doaj   +1 more source

Genetic Characterization of a New HIV-1 Sub-Subtype A in Cabo Verde, Denominated A8

Viruses, 2021
Previous molecular characterization of Human immunodeficiency virus (HIV-1) samples from Cabo Verde pointed out a vast HIV-1 pol diversity, with several subtypes and recombinant forms, being 5.2% classified as AU-pol.
Rayana Katylin Mendes Da Silva, Isabel Inês Monteiro de Pina Araujo, Karine Venegas Maciera, Mariza Gonçalves Morgado, Monick Lindenmeyer Guimarães   +4 more
doaj   +1 more source

Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis [PDF]

Frontiers in Immunology, 2019
Fc receptor (FcR) genes collectively have copy number and allelic polymorphisms that have been implicated in multiple inflammatory and autoimmune diseases. This variation might also be involved in etiology of infectious diseases. The protective role of Fc-mediated antibody-function in HIV-1 immunity has led to the investigation of specific ...
Daniel E. Geraghty, Christian W. Thorball, Jacques Fellay, Jacques Fellay, Rasmi Thomas, Rasmi Thomas   +5 more
openaire   +4 more sources

Genetic diversity of Vif protein in human immunodeficiency virus type 1 variants (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1) that circulated in the Moscow region in 2019–2020

Вопросы вирусологии
Introduction. The Vif protein counteracts cellular deaminases, APOBEC3, which prevent viral replication. Vif is used for development of therapeutic agents.
Anastasiia A. Antonova, Larisa A. Protasova, Kristina V. Kim, Iana M. Munchak, Ekaterina N. Mezhenskaya, Elena A. Orlova-Morozova, Alexander Yu. Pronin, Alexey G. Prilipov, Anna I. Kuznetsova   +8 more
doaj   +1 more source

Deep-sequencing of viral genomes from a large and diverse cohort of treatment-naive HIV-infected persons shows associations between intrahost genetic diversity and viral load.

PLoS Computational Biology, 2023
BackgroundInfection with human immunodeficiency virus type 1 (HIV) typically results from transmission of a small and genetically uniform viral population.
Migle Gabrielaite, Marc Bennedbæk, Malthe Sebro Rasmussen, Virginia Kan, Hansjakob Furrer, Robert Flisiak, Marcelo Losso, Jens D Lundgren, INSIGHT START Study Group, Rasmus L Marvig   +9 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Viral Envelope Evolution in Simian–HIV-Infected Neonate and Adult-Dam Pairs of Rhesus Macaques

Viruses
We recently demonstrated that Simian–HIV (SHIV)-infected neonate rhesus macaques (RMs) generated heterologous HIV-1 neutralizing antibodies (NAbs) with broadly-NAb (bNAb) characteristics at a higher frequency compared with their corresponding dam.
Elena E. Giorgi, Hui Li, Bhavna Hora, George M. Shaw, Kshitij Wagh, Wilton B. Williams   +5 more
doaj   +1 more source