Results 61 to 70 of about 30,382,849 (226)

HIV-1 integrase polymorphisms are associated with prior antiretroviral drug exposure

Retrovirology, 2009
In a recent summary of integrase sequences, primary integrase inhibitor mutations were rare. In a review of integrase inhibitor-naïve Australian HIV-1 sequences, primary mutations were not identified, although the accessory mutation G140S was detected. A
Wang Bin, Deris Zaquan, Herring Belinda, van Hal Sebastiaan J, Saksena Nitin K, Dwyer Dominic E   +5 more
doaj   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products [PDF]

Journal of Medicinal Chemistry, 2010
Anti-HIV peptides with inhibitory activity against HIV-1 integrase (IN) have been found in overlapping peptide libraries derived from HIV-1 gene products. In a strand transfer assay using IN, inhibitory active peptides with certain sequential motifs related to Vpr- and Env-derived peptides were found.
Shintaro Suzuki, Urano, Emiko, Chie Hashimoto, Hiroshi Tsutsumi, Toru Nakahara, Tomohiro Tanaka, Yuta Nakanishi, Maddali, Kasthuraiah, Han, Yan, Hamatake, Makiko, Miyauchi, Kosuke, Pommie, Yves, Beutler, John A., Sugiura, Wataru, Fuji, Hideyoshi, Hoshino, Tyuji, Kyoko Itotani, Wataru Nomura, Tetsuo Narumi, Naoki Yamamoto, Atsushi Komano, Hirokazu Tamamura   +21 more
openaire   +2 more sources

Effects of HIV type-1 immune selection on susceptability to integrase inhibitor resistance [PDF]

, 2009
Background: All site-specific interactions between HIV type-1 (HIV-1) subtype, human leukocyte antigen (HLA)-associated immune selection and integrase inhibitor resistance are not completely understood.
Chopra, A., Günthard, Huldrych F, John, Mina, James, Ian, Furrer, H, Ahmad, Imran F, Ahmad, I.F., Chopra, A, Rauch, A., Ahmad, I F, Rauch, A, John, M., James, I, Furrer, Hansjakob, Tschochner, M., Furrer, H., Günthard, H., Chopra, Abha, Rauch, Andri, John, M, Mallal, Simon, Maiden, T.M., Günthard, H F, Tschochner, Monika, Mallal, S, Tschochner, M, James, I., Maiden, Tanya M, Mallal, S., Maiden, T M   +29 more
core   +1 more source

Non–AIDS‐Defining Cancer Incidence in People With HIV in Milan, Italy, 2000–2023: Temporal Trends and Comparison With the General Population

International Journal of Cancer, EarlyView.
ABSTRACT People with HIV (PWH) are living longer, but contemporary data on non–AIDS‐defining cancers (NADCs) in Italy remain limited. We assessed incident cancers in a retrospective cohort of PWH in Milan, Italy, between January 2000 and December 2023. Follow‐up was grouped into 2000–2007, 2008–2015, and 2016–2023. Incidence rates (IRs) were calculated
Giacomo Pozza, Maddalena Matone, Letizia Oreni, Giorgia Carrozzo, Beatrice Caloni, Maria Vittoria Cossu, Davide Moschese, Anna Lisa Ridolfo, Cristina Gervasoni, Cinzia Fasola, Nicla La Verde, Davide Dalu, Spinello Antinori, Andrea Gori, Andrea Giacomelli   +14 more
wiley   +1 more source

Integrase inhibitors in the treatment of HIV-1 infection [PDF]

Journal of Antimicrobial Chemotherapy, 2010
Agents active against HIV type 1 (HIV-1) that target the viral integrase by inhibiting the strand transfer step of integration have now entered the clinical arena. Raltegravir is the first in this new class. Clinical trials in treatment-experienced and in treatment-naive patients have shown that raltegravir-containing regimens have potent ...
openaire   +2 more sources

Synthesis of New Potential HIV-1 Integrase Inhibitors [PDF]

HETEROCYCLES, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
FERRO, Stefania, RAO, Angela, ZAPPALA', Maria, CHIMIRRI, Alba, BARRECA, Maria Letizia, WITVROUW M, DEBYSER Z, MONFORTE, Pietro   +7 more
openaire   +4 more sources

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Activity of recombinant HIV-1 integrase on mini-HIV DNA [PDF]

, 1999
Integration of the human immunodeficiency virus type 1 (HIV-1) cDNA into the genome of a human cell is an essential step in the viral replication cycle.
Cherepanov, Peter, De Clercq, Erik, Surratt, David, Debyser, Zeger, Pluymers, Wim, Toelen, Jaan, Griffith, Jack   +6 more
core   +1 more source

CD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjects

Journal of Translational Medicine, 2004
Background CD8+ T cell responses are known to be important to the control of HIV-1 infection. While responses to reverse transcriptase and most structural and accessory proteins have been extensively studied, CD8 T cell responses specifically directed to
Yu Xu G, Fitzpatrick Cecily A, Rathod Almas, Addo Marylyn M, Rodriguez William R, Perkins Beth, Rosenberg Eric S, Altfeld Marcus, Walker Bruce D   +8 more
doaj   +1 more source