Results 81 to 90 of about 30,382,849 (226)
How HIV-1 Integrase Associates with Human Mitochondrial Lysyl-tRNA Synthetase
Viruses, 2020 Replication of human immunodeficiency virus type 1 (HIV-1) requires the packaging of tRNALys,3 from the host cell into the new viral particles. The GagPol viral polyprotein precursor associates with mitochondrial lysyl-tRNA synthetase (mLysRS) in a ...
Xaysongkhame Phongsavanh +7 more
doaj +1 more source
In vitro HIV-1 LTR integration into T-cell activation gene CD27 segment and the decoy effect of modified-sequence DNA. [PDF]
PLoS ONE, 2012 Integration into the host genome is an essential step in the HIV-1 life cycle. However, the host genome sequence that is favored by HIV-1 during integration has never been documented.
Rei Ohmori, Tatsuaki Tsuruyama
doaj +1 more source
HIV Medicine, EarlyView.Abstract Objectives To describe the sociodemographic characteristics, migration patterns and immunovirological outcomes of Venezuelan migrants living with HIV (PLWH) in Barcelona, Spain, and to compare them with other Latin American (LA) migrant PLWH. Methods We conducted a retrospective observational cohort study including LA migrant PLWH who attended
Alexy Inciarte +17 more
wiley +1 more source
A hybrid lentivirus-transposon vector for safer gene therapy [PDF]
, 2010 Gene therapy vectors based on the HIV-1 lentivirus are an attractive option for clinical applications because they enter a broad range of target cells efficiently and deliver stable gene expression through integration into host chromosomes.
Vink, C.A.
core
HIV Medicine, EarlyView.Abstract Objective To describe real‐world patterns of use, virologic and immunologic outcomes and treatment persistence among people with HIV (PWH) initiating fostemsavir (FTR) in a diverse US cohort. Design Retrospective cohort study of adults receiving FTR in clinical practice, stratified by baseline viral suppression status.
Richard Elion +10 more
wiley +1 more source
Anti-HIV therapy: pipeline approaches and future directions [PDF]
, 2011 Human immunodeficiency virus (HIV), with about 30 million deaths and double infections (in developing countries), is an open challenge today for global scientists.
Lavkush Dwivedi, Mansi Shrivastava
core +1 more source
mBio, 2017 Resistance to the integrase strand transfer inhibitors raltegravir and elvitegravir is often due to well-identified mutations in the integrase gene. However, the situation is less clear for patients who fail dolutegravir treatment.
Isabelle Malet +7 more
doaj +1 more source
Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration. [PDF]
PLoS ONE, 2009 BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) integrase protein (IN), catalyzes the integration of viral DNA into the host cell genome. IN catalyzes the first step of the integration process, namely the 3'-end processing in which IN removes
Aviad Levin +5 more
doaj +1 more source
HIV Medicine, EarlyView.Abstract Background Prior to the COVID‐19 pandemic, antiretroviral therapy (ART) coverage and viral suppression were improving across Europe; however, the impact of the pandemic on HIV care remains uncertain. Methods In‐person visits, ART coverage and viral suppression among those on ART were described in the EuroSIDA cohort for each calendar year from
Olga Fursa +18 more
wiley +1 more source
Assessment of Integration-defective HIV-1 and EIAV Vectors In Vitro and In Vivo
Molecular Therapy: Nucleic Acids, 2012 The interest in integrase-defective lentiviral vectors (IDLVs) stems from their potential advantage of large cloning capacity and broad cell tropism while avoiding the possibility of insertional mutagenesis.
Scott Ellis +5 more
doaj +1 more source