Results 211 to 220 of about 89,605 (248)

Pharmacokinetics of Atorvastatin and Metformin after Coadministration with Islatravir in Healthy Adults

The Journal of Clinical Pharmacology, EarlyView.
Abstract Islatravir, a deoxyadenosine analog that inhibits HIV‐1 replication by multiple mechanisms of action, including reverse transcriptase translocation inhibition, is being developed for use in HIV‐1 treatment. People living with HIV often have comorbidities, such as dyslipidemia or type 2 diabetes mellitus, necessitating long‐term concomitant ...
Jacqueline B. McCrea, Munjal Patel, Yang Liu, Ryan Vargo, Rose Witter, Andrew Litovsky, S. Aubrey Stoch, Marian Iwamoto, Randolph P. Matthews   +8 more
wiley   +1 more source

8 Implication of the HIV-1 pol gene intragenic enhancer in myeloid-specific viral gene expression

Journal of Virus Eradication, 2017
R. Verdikt, L. Colin, C. Vanhulle, B. Van Driessche, A. Kula, V. Monceaux, N. Delacourt, A. David, A. Saez-Cirion, C. Van Lint   +9 more
doaj  

Clinical Assessment of the Drug–Drug Interaction Potential of Omaveloxolone in Healthy Adult Participants

The Journal of Clinical Pharmacology, EarlyView.
Abstract Omaveloxolone is approved in the United States and the European Union for the treatment of patients with Friedreich ataxia aged ≥16 years. It is mainly metabolized by cytochrome P450 (CYP) 3A4 in vitro. Two drug–drug interaction studies (NCT04008186 and NCT05909644) were performed to evaluate (1) the effect of drug‐metabolizing enzymes (DMEs ...
Hamim Zahir, Masako Murai, Lucy Wu, Michelle Valentine, Scott Hynes   +4 more
wiley   +1 more source

Efanesoctocog Alfa Population Pharmacokinetics and Repeated Time‐To‐Event Analysis of Bleeds in Adults, Adolescents, and Children with Severe Hemophilia A

The Journal of Clinical Pharmacology, EarlyView.
Abstract Efanesoctocog alfa is a first‐in‐class high‐sustained factor VIII (HSF) replacement therapy for treatment of hemophilia A. This article presents population pharmacokinetics (PopPK) of efanesoctocog alfa and repeated time‐to‐event (RTTE) analysis of bleeding episodes in adults/adolescents (≥12 years of age) and children (<12 years).
Nancy Wong, Pratik Bhagunde, Joakim Nyberg, Suresh Katragadda, Marek Demissie, Annemieke Willemze, Craig Benson, Sreeraj Macha   +7 more
wiley   +1 more source

Shining stars in the sky on the gastric mucosa

Journal of General and Family Medicine, EarlyView.
We report a rare case of an elderly Japanese man diagnosed with sporadic gastric Burkitt lymphoma. Esophagogastroduodenoscopy showed nodular and ulcerated lesions in the lesser curvature of the stomach. Pathological analysis of showed that the gastric lesions are characterized by a diffuse and dense accumulation of dark atypical lymphocytes (night) and
Kosuke Minaga, Hajime Honjo, Tomohiro Watanabe, Masatoshi Kudo   +3 more
wiley   +1 more source

35 Therapy with the immunomodulatory agent pomalidomide does not lead to changes in HIV-1 viral populations in vivo

Journal of Virus Eradication, 2016
S.A. Watters, M.N. Polizzotto, W. Shao, R. Gorelick, E.M. Anderson, I. Sereti, K. Aleman, L. Kouyoudjian, J.B. Zeldis, T. Uldrick, R. Yarchoan, F. Maldarelli   +11 more
doaj  

Erosive and annular lesions of the gastric mucosa: Not negligible signs of Treponema pallidum infection

Journal of General and Family Medicine, EarlyView.
Giulia Ciccarese, Antonio Facciorusso, Vanessa De Pace, Francesco Drago   +3 more
wiley   +1 more source

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HIV infection

Nature Reviews Disease Primers, 2023
The AIDS epidemic has been a global public health issue for more than 40 years and has resulted in ~40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted via body fluids and secretions. After infection, the virus invades host cells by attaching to CD4 receptors and thereafter one of two major chemokine coreceptors, CCR5 or ...
Linda-Gail Bekker, Chris Beyrer, Nyaradzo Mgodi, Sharon R. Lewin, Sinead Delany-Moretlwe, Babafemi Taiwo, Mary Clare Masters, Jeffrey V. Lazarus   +7 more
openaire   +2 more sources

Silent HIV infection

Vaccine, 1993
The period of latency between infection by the human immunodeficiency virus type-1 (HIV-1) and the production of specific antibodies to viral antigens may be prolonged and, occasionally, may last for years. This condition of seronegative infection could represent a serious risk of viral transmission from subjects who are unaware of their status ...
AIUTI, Fernando, ENSOLI F, FIORELLI V, MEZZAROMA, Ivano, PINTER, Elena, GUERRA E, VARANI AR   +6 more
openaire   +4 more sources

The Lymphadenopathy of HIV Infection

American Journal of Clinical Pathology, 1993
The increase in the number of HIV-infected patients and the progression of the disease into the acquired immunodeficiency syndrome (AIDS)' have stimulated wide-spread attention. The result has been a better knowledge of the pathogenesis of AIDS. Variations in severity at the onset and in the progression of the disease, which possibly are related to the
Baroni CD, UCCINI, Stefania
openaire   +3 more sources