Results 161 to 170 of about 2,695,708 (355)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.

New England Journal of Medicine, 2012
J. Baeten, D. Donnell, P. Ndase, N. Mugo, J. Campbell, Jonathan Wangisi, J. Tappero, E. Bukusi, C. Cohen, E. Katabira, A. Ronald, Elioda Tumwesigye, E. Were, K. Fife, J. Kiarie, C. Farquhar, G. John-Stewart, Aloysious Kakia, J. Odoyo, A. Mucunguzi, E. Nakku-Joloba, R. Twesigye, K. Ngure, Cosmas Apaka, H. Tamooh, Fridah Gabona, A. Mujugira, D. Panteleeff, Katherine K. Thomas, L. Kidoguchi, M. Krows, Jennifer Revall, Susan Morrison, Harald S. Haugen, Mira Emmanuel-ogier, Lisa Ondrejcek, R. Coombs, L. Frenkel, C. Hendrix, Namandjé N. Bumpus, D. Bangsberg, J. Haberer, W. Stevens, J. Lingappa, C. Celum   +44 more
semanticscholar   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

HIV gag; HIV p27 (nef); HIV pol; HIV env [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

HIV testing [PDF]

BMJ, 2005
Kaveh, Manavi, Philip D, Welsby
openaire   +2 more sources

1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults.

MMWR Recommendations and Reports, 1993
K. Castro, J. Ward, L. Slutsker, J. Buehler, H. Jaffe, R. Berkelman, J. Curran   +6 more
semanticscholar   +1 more source

Navigating an STI diagnosis: The role of social support, intergenerational learning, and transformative growth among Black women

American Journal of Community Psychology, EarlyView.
Abstract Black women face a myriad of challenges that heighten their susceptibility to sexually transmitted infections (STIs), resulting in a disproportionate impact of STIs among this population. Yet, there is a lack of research that explores how women navigate these diagnoses with resilience.
Jaleah D. Rutledge, Jasmine Abrams, Ijeoma Opara, Robin Lin Miller   +3 more
wiley   +1 more source

The intersection of health inequalities and COVID‐19: Evidence from National Health Insurance Big Data in South Korea

American Journal of Community Psychology, EarlyView.
Abstract Health inequalities persist along lines of income and wealth, shaped by unequal access to healthcare, differences in health behaviors, and pre‐existing chronic conditions. The COVID‐19 pandemic further put families in Korea under health strain and worsened their health outcomes.
Jaehyun Nam, Sarah Jiyoon Kwon, Wonik Lee, Eunji Kim   +3 more
wiley   +1 more source

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

Animal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai, Xintao Zhang, Tingting Luo, Wenhan Chen, Chenyu Ma, Haihua Luo, Jinghua Liu, Jia Xu   +7 more
wiley   +1 more source

Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents, January 28, 2000

HIV Clinical Trials, 1998
A. Fauci, J. Bartlett, E. Goosby, M. D. Smith, H. Kaiser, S. Chang, Jean R. Anderson, R. Armstead, A. Baker, David P. Barr, S. Bozzette, S. Cox, M. Delaney, F. Gordin, W. Greaves, M. Harrington, J. Henning, M. Hirsch, J. Jacobs, R. Marlink, C. Maxwell, J. Mellors, D. Nash, S. Perryman, R. Schooley, R. Sherer, S. Spector, G. Torres, P. Volberding, B. A. Brady, E. M. Daniels, D. Feigal, M. Feinberg, H. Gayle, T. Graydon, J. Kaplan, A. Macher, R. F. Martin, H. Masur, L. Mofenson, J. Murray, J. O'Neill, L. C. Perez, R. Riseberg, S. Shekar, S. Stanley, J. Whitescarver   +46 more
semanticscholar   +1 more source