Results 221 to 230 of about 2,695,708 (355)

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

Nature, 2019
Ravindra K. Gupta, Sultan Abdul-Jawad, Laura E. McCoy, H. Mok, D. Peppa, M. Salgado, J. Martinez-Picado, M. Nijhuis, A. Wensing, Helen H. Lee, P. Grant, Eleni Nastouli, J. Lambert, M. Pace, F. Salasc, C. Monit, A. Innes, L. Muir, L. Waters, J. Frater, A. Lever, S. Edwards, I. Gabriel, E. Olavarría   +23 more
semanticscholar   +1 more source

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

HIV-1 Prevalence and Oral Pre-Exposure Prophylaxis Effectiveness and Prevalence of Use Among Key Populations in High-Income Economies (2017-2023): A Systematic Review and Meta-Analysis of Real-World Studies. [PDF]

Open Forum Infect Dis
Huang X, Mezzio D, Yang J, Najarro Cermeño J, Navadeh S, Tao L.   +5 more
europepmc   +1 more source

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Health Literacy, Knowledge of HIV/AIDS, and Public Stigma Among General Citizens of Japan: An Online Cross-Sectional Survey. [PDF]

J Int Assoc Provid AIDS Care
Togari T, Inoue Y, Abe S.
europepmc   +1 more source

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

Nature, 2008
S. Neil, Trinity M Zang, P. Bieniasz
semanticscholar   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Impact of Universal Test and Treat (UTT) on anticipated stigma among patients newly diagnosed with HIV in Johannesburg, South Africa: A cross-sectional study. [PDF]

PLOS Glob Public Health
Sineke T, Mokhele I, Ruiter RAC, Dukashe M, Onoya D.   +4 more
europepmc   +1 more source

PKRxiv: A Best Practice Model for Advancing Pharmacoequity Through Open Pharmacokinetic Data Sharing

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development is increasingly integrated across the drug development continuum, enabling more efficient, cost‐effective, and targeted trials while reducing reliance on animal studies. Achieving pharmacoequity requires not only equitable access to medicines but also to the data and knowledge that inform drug development and regulatory ...
Shakir Atoyebi, Prajith Venkatasubramanian, Abdulafeez Akinloye, Oluwasegun Eniayewu, Brookie M. Best, Laura Else, Adeniyi Olagunju   +6 more
wiley   +1 more source

Complement and Coagulation Cascades Pathway was Inactivated in HIV-Associated Colorectal Cancer: Results from a Proteomics Study. [PDF]

J Cancer
Lian S, Li L, Yang Y, Liu S, Song S, Zhang L.   +5 more
europepmc   +1 more source