Results 121 to 130 of about 696,413 (247)

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Healthcare services provided to pregnant women with HIV and their outcomes at primary healthcare clinics in the Free State province, South Africa. [PDF]

South Afr J HIV Med
Khaliq OP, Jassen A, Tabane NE, Moodley J.   +3 more
europepmc   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

SMAC mimetics reverse HIV latency by selective activation of the non-canonical NF-κB pathway

Journal of Virus Eradication, 2017
G.C. Sampey, D.M. Irlbeck, D.M. Margolis, R.M. Dunham, E.P. Brownel   +4 more
doaj   +1 more source

Integration of HIV Status in Cancer Surveillance in South Africa: A Call for Action. [PDF]

Cancer Med
Metekoua C, Wiggill T, Tombe-Nyahuma T, Ruffieux Y, Mwansa-Kambafwile J, Kwenda S, Dhokotera TG, Bohlius J, Rohner E, Muchengeti M.   +9 more
europepmc   +1 more source

Recent Advances in Chemical Probing Strategies for RNA Structure Determination in Vivo

Chemistry – A European Journal, EarlyView.
This Review illustrates how structural probes combined with advanced sequencing technologies are revolutionizing our ability to map RNA structures and interactions within living cells. It highlights the development of innovative strategies tailored to probe RNA structures in particular biological contexts.
Maryana Yarshova, Jieyu Zhao, Chun Kit Kwok   +2 more
wiley   +1 more source

A comparative analysis of HIV status by sociodemographic and sexual behavior characteristics among men in Bexar county, Texas: An Ending the HIV Epidemic priority county. [PDF]

PLoS One
Delgado AJ, Cossman JS, BeLue R.
europepmc   +1 more source

Trial of mailed specimen collection for HIV testing in regional Queensland

Australian and New Zealand Journal of Public Health, 2014
William Rutkin, Joseph Debattista, Patrick Martin, John Hooper   +3 more
doaj   +1 more source

Barriers and facilitators to HIV testing among transgender people in Georgia: Qualitative study results using the COM-B Framework. [PDF]

PLOS Glob Public Health
Gogia M, Zurashvili T, DeHovitz J, Djibuti M.   +3 more
europepmc   +1 more source

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source