Results 121 to 130 of about 1,402,138 (245)

Transforming RNA Degradation into Accurate RNA Detection: RNase I–Assisted Rolling Circle Amplification for Clinical Samples

Angewandte Chemie, EarlyView.
Here, we transform this otherwise destructive enzymatic activity into a powerful diagnostic advantage through an RNase I–assisted rolling circle amplification (RI‐RCA) strategy. By integrating controlled RNase I–mediated RNA digestion with circular DNA templates, this approach enables direct and highly sensitive detection of target RNA sequences. Using
Amal Mathai, Cheng‐Yu Lee, Zijie Zhang, Jimmy Gu, John D. Brennan, Yingfu Li   +5 more
wiley   +2 more sources

Evaluation of the HIV Case-Based Surveillance System in Dire Dawa City Administration, Ethiopia. A Descriptive Cross-Sectional Study. [PDF]

AIDS Res Treat
Hagos F, Kassahun A, Sisay A.
europepmc   +1 more source

Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.

New England Journal of Medicine, 2015
J. Lundgren, A. Babiker, F. Gordin, S. Emery, B. Grund, Shweta Sharma, A. Avihingsanon, D. Cooper, G. Fätkenheuer, J. Llibre, J. Molina, P. Munderi, M. Schechter, R. Wood, K. Klingman, S. Collins, H. Lane, A. Phillips, J. Neaton   +18 more
semanticscholar   +1 more source

The intersection of health inequalities and COVID‐19: Evidence from National Health Insurance Big Data in South Korea

American Journal of Community Psychology, EarlyView.
Abstract Health inequalities persist along lines of income and wealth, shaped by unequal access to healthcare, differences in health behaviors, and pre‐existing chronic conditions. The COVID‐19 pandemic further put families in Korea under health strain and worsened their health outcomes.
Jaehyun Nam, Sarah Jiyoon Kwon, Wonik Lee, Eunji Kim   +3 more
wiley   +1 more source

HIV-1 Prevalence and Oral Pre-Exposure Prophylaxis Effectiveness and Prevalence of Use Among Key Populations in High-Income Economies (2017-2023): A Systematic Review and Meta-Analysis of Real-World Studies. [PDF]

Open Forum Infect Dis
Huang X, Mezzio D, Yang J, Najarro Cermeño J, Navadeh S, Tao L.   +5 more
europepmc   +1 more source

Multimorbidity and animal models

Animal Models and Experimental Medicine, EarlyView.
Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang, Yakun Ren, Xingjiu Yang, Mengyuan Li, Junxiu Liu, Xiaoyan Du, Wen Wang, Ran Gao   +7 more
wiley   +1 more source

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

Animal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai, Xintao Zhang, Tingting Luo, Wenhan Chen, Chenyu Ma, Haihua Luo, Jinghua Liu, Jia Xu   +7 more
wiley   +1 more source

HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir. [PDF]

Elife
van Paassen PM, Pasternak AO, Bolluyt DC, van Dort KA, van Nuenen AC, Maurer I, Boeser-Nunnink B, Buchholtz NVEJ, Mahmoudi T, Lungu C, van Crevel R, Rokx C, Symons J, Nijhuis M, van der Veen ALIP, Vogt L, Klouwens MJ, Prins JM, Kootstra NA, de Bree GJ.   +19 more
europepmc   +1 more source

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Nature, 2006
C. Day, D. Kaufmann, P. Kiepiela, Julia A. Brown, Eshia S. Moodley, S. Reddy, Elizabeth W. Mackey, Joseph D. Miller, A. Leslie, Chantal DePierres, Z. Mncube, Jaikumar Duraiswamy, Baogong Zhu, Q. Eichbaum, M. Altfeld, E. Wherry, H. Coovadia, P. Goulder, P. Goulder, P. Goulder, P. Klenerman, R. Ahmed, G. Freeman, B. D. Walker, B. D. Walker, B. D. Walker   +25 more
semanticscholar   +1 more source

SMAC mimetics reverse HIV latency by selective activation of the non-canonical NF-κB pathway

Journal of Virus Eradication, 2017
G.C. Sampey, D.M. Irlbeck, D.M. Margolis, R.M. Dunham, E.P. Brownel   +4 more
doaj   +1 more source