Results 121 to 130 of about 2,775,555 (408)

Southern African HIV Clinicians Society Conference – Striving for Clinical Excellence, 2012 – Best Abstracts

Southern African Journal of HIV Medicine, 2013
Over 100 scientific abstracts were submitted for consideration by the scientific programme committee of the Society's conference, Striving for Clinical Excellence.
Southern African HIV Clinicians Society
doaj   +1 more source

HIV testing intervention development among men who have sex with men in the developed world [PDF]

, 2017
HIV testing is a ‘gateway’ technology, enabling access to treatment and HIV prevention. Biomedical approaches to prevention, such as pre-exposure prophylaxis and treatment as prevention, require accurate and regular HIV test results.
Burns, Fiona, Estcourt, Claudia, Flowers, Paul, Sonnenberg, Pam   +3 more
core   +4 more sources

On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection.

New England Journal of Medicine, 2015
BACKGROUND Antiretroviral preexposure prophylaxis has been shown to reduce the risk of human immunodeficiency virus type 1 (HIV-1) infection in some studies, but conflicting results have been reported among studies, probably due to challenges of ...
J. Molina, C. Capitant, B. Spire, G. Pialoux, L. Cotte, I. Charreau, C. Tremblay, J. Le Gall, E. Cua, A. Pasquet, F. Raffi, C. Pintado, C. Chidiac, J. Chas, P. Charbonneau, C. Delaugerre, M. Suzan-Monti, B. Loze, J. Fonsart, G. Peytavin, A. Chéret, J. Timsit, G. Girard, N. Lorente, M. Préau, J. Rooney, M. Wainberg, D. Thompson, W. Rozenbaum, V. Doré, L. Marchand, M. Simon, N. Etien, J. Aboulker, L. Meyer, J. Delfraissy   +35 more
semanticscholar   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Analysis of a Stochastic Predator-Prey Model with Applications to Intrahost HIV Genetic Diversity [PDF]

arXiv, 2009
During an infection, HIV experiences strong selection by immune system T cells. Recent experimental work has shown that MHC escape mutations form an important pathway for HIV to avoid such selection. In this paper, we study a model of MHC escape mutation.
arxiv  

Global Burden of Atherosclerotic Cardiovascular Disease in People Living With HIV: Systematic Review and Meta-Analysis

Circulation, 2018
Background: With advances in antiretroviral therapy, most deaths in people with HIV are now attributable to noncommunicable illnesses, especially cardiovascular disease.
Anoop S. V. Shah, D. Stelzle, K. Lee, E. Beck, S. Alam, S. Clifford, C. Longenecker, F. Strachan, Shashwatee Bagchi, W. Whiteley, S. Rajagopalan, S. Kottilil, H. Nair, D. Newby, D. McAllister, N. Mills   +15 more
semanticscholar   +1 more source

Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo

Advanced Science, EarlyView.
Network‐based risk stratification of people living with HIV (PWH) on prolonged therapy using multi‐omics data identifies 44% of the patients are at risk of immunometabolic complications. A senescence‐associated myeloid cell‐driven plasma microenvironment drives immunometabolic dysregulation in at‐risk PWH.
Flora Mikaeloff, Marco Gelpi, Alejandra Escós, Tianqi Wang, Soham Gupta, Anna Olofsson, Sara Svensson Akusjärvi, Sabrina Schuster, Prajakta Naval, Vikas Sood, Negin Nikouyan, Andreas D. Knudsen, Beate Vestad, Julie Høgh, Johannes R. Hov, Thomas Benfield, Marius Trøseid, Vinay Pawar, Marijana Rucevic, Rui Benfeitas, Ákos Végvári, Liam O'Mahony, Rajkumar Savai, Niklas K. Björkström, Magda Lourda, João Pedro de Magalhães, Siegfried Weiss, Adil Mardinoglu, Mukesh Kumar Varshney, Annika C. Karlsson, Yasir Ahmed Syed, Susanne D. Nielsen, Ujjwal Neogi   +32 more
wiley   +1 more source

Tabah Sampai Akhir [PDF]

, 2017
AIDS (Acquired Immune Deficiency Syndrome) merupakan satu gejala penyakit atau sindroma yang dapat menyebabkan sistem kekebalan tubuh seseorang menjadi lemah yang disebabkan oleh virus HIV.
Masykur , Achmad Mujab, Swastika , Yonanda Ade Ayu   +1 more
core  

An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors

Advanced Science, EarlyView.
A peptide library screening platform has been developed to discover covalent transcription factor inhibitors. It identifies an antagonist cysteine residue, which forms an inhibitory disulphide with cJun C269. Conversion of this cysteine to an electrophile generates an irreversible and selective cJun inhibitor, validating this approach for covalent ...
Andrew Brennan, Scott Lovell, Keith W Vance, Jody M Mason   +3 more
wiley   +1 more source

Catalyst‐Free Direct Hydrocarbonation of Terminal Alkynes Toward E‐Alkene Substituted Stabilized Sulfoxonium Ylides

Advanced Science, EarlyView.
The authors introduce a high‐throughput synthesis using amide‐sulfoxonium ylides as new nucleophilic reagents, enabling a catalyst‐ and base‐free hydrocarbonation of terminal alkynes under mild conditions, resulting in various E‐alkene substituted (hetero)amide‐sulfoxonium ylides with excellent regio‐ and stereoselectivity. The late‐stage modifications
Haiting Wu, Yougen Xu, An Lin, Jingyuan Liu, Huanjun Chen, Shimin Xie, Lebin Su   +6 more
wiley   +1 more source