Results 21 to 30 of about 1,402,138 (245)

Evolution of Risk Behaviors, Sexually Transmitted Infections and PrEP Care Continuum in a Hospital-Based PrEP Program in Barcelona, Spain: A Descriptive Study of the First 2 Years’ Experience

Infectious Diseases and Therapy, 2022
Introduction Pre-exposure prophylaxis (PrEP) is effective for HIV prevention, but the PrEP care continuum also involves improving PrEP awareness, uptake, adherence, and retention in care.
Ainoa Ugarte, Lorena de la Mora, David García, María Martínez-Rebollar, Elisa de Lazzari, Berta Torres, Alexy Inciarte, Juan Ambrosioni, Iván Chivite, Estela Solbes, Nicolás de Loredo, Guillermo Federico Del Carlo, Ana González-Cordón, José Luis Blanco, Esteban Martínez, Josep Mallolas, Montserrat Laguno   +16 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Transcriptional landscape of Kaposi sarcoma tumors identifies unique immunologic signatures and key determinants of angiogenesis

Journal of Translational Medicine, 2023
Background Kaposi sarcoma (KS) is a multicentric tumor caused by Kaposi sarcoma herpesvirus (KSHV) that leads to morbidity and mortality among people with HIV worldwide.
Ramya Ramaswami, Takanobu Tagawa, Guruswamy Mahesh, Anna Serquina, Vishal Koparde, Kathryn Lurain, Sarah Dremel, Xiaofan Li, Ameera Mungale, Alex Beran, Zoe Weaver Ohler, Laura Bassel, Andrew Warner, Ralph Mangusan, Anaida Widell, Irene Ekwede, Laurie T. Krug, Thomas S. Uldrick, Robert Yarchoan, Joseph M. Ziegelbauer   +19 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Poor post‐exposure prophylaxis completion despite improvements in post‐violence service delivery in 14 PEPFAR‐supported sub‐Saharan African countries, 2018–2023

Journal of the International AIDS Society
Introduction Sexual violence (SV) affects millions globally and has a well‐documented bidirectional association with HIV. Post‐exposure prophylaxis (PEP) is a critical, yet often underutilized, HIV prevention tool in post‐SV care.
Udhayashankar Kanagasabai, Stephanie M. Davis, Viva Thorsen, Emily Rowlinson, Anne Laterra, Jennifer Hegle, Carrine Angumua, Alexandre Ekra, Minlangu Mpingulu, Meklit Getahun, Fikirte Sida, Phumzile Mndzebele, Caroline Kambona, Puleng Ramphalla, Eunice Mtingwi, Wezi Msungama, Meghan Duffy, Bukola Adewumi, Ezeomu Olotu, Jackson Sebeza, Jane Kitalile, Rose Apondi, Carlos Muleya, Meagan Cain   +23 more
doaj   +1 more source

The impact of lookback windows on the prevalence and incidence of chronic diseases among people living with HIV: an exploration in administrative health data in Canada

BMC Medical Research Methodology, 2022
Background We described the impact of different lengths of lookback window (LW), a retrospective time period to observe diagnoses in administrative data, on the prevalence and incidence of eight chronic diseases.
Ni Gusti Ayu Nanditha, Xinzhe Dong, Taylor McLinden, Paul Sereda, Jacek Kopec, Robert S. Hogg, Julio S. G. Montaner, Viviane D. Lima   +7 more
doaj   +1 more source

Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial

PLoS Medicine, 2005
Background Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis.
B. Auvert, D. Taljaard, E. Lagarde, J. Sobngwi-Tambekou, R. Sitta, A. Puren   +5 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Positivity rate, trend and associated risk factors of mother-to-child transmission of HIV among HIV-exposed infants

BMC Pediatrics, 2023
Background Mother-To-Child-Transmission (MTCT) of Human Immunodeficiency Virus (HIV) occurs during pregnancy, delivery and breastfeeding, and cause infection among several new-borns.
Gadissa Gutema, Habteyes Hailu Tola, Dinka Fikadu, Dereje Leta, Birra Bejiga, Jaleta Bulti Tura, Saro Abdella, Hassen Mamo   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source