Results 61 to 70 of about 2,248,861 (362)

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

Parenting and HIV

Current Opinion in Psychology, 2017
With the widespread use of antiretroviral therapy and successful prevention of mother-to-child transmission the development of HIV-negative children with HIV-positive parents has become an important focus. There is considerable evidence that children's developmental risk is heightened because a parental HIV-diagnosis is associated with a range of ...
Alan Stein, Alan Stein, Elena Netsi, Stephanie Redinger, Tamsen J. Rochat   +4 more
openaire   +3 more sources

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

An investigation of factors associated with the health and well-being of HIV-infected or HIV-affected older people in rural South Africa [PDF]

, 2012
BackgroundDespite the severe impact of HIV in sub-Saharan Africa, the health of older people aged 50+ is often overlooked owing to the dearth of data on the direct and indirect effects of HIV on older people's health status and well-being.
A Razzaque, AJ Herbst, B Curtis, BB Reeve, BB Reeve, BM Mayosi, C Ardington, C Debpuur, C Kyobutungi, C Wallrauch, CF Houlihan, D Posel, DW Wang, E Duflo, E Wouters, EJ Schatz, F Scholten, F Tanser, F Xavier Gomez-Olive, G Louwagie, GH Ice, H Boon, H Van Minh, H Van Minh, J Burns, J Joubert, Jane Falkingham, K Kahn, K Kahn, K Kinsella, K Peltzer, L Gilbert, LC Hamilton, LR Fairall, M Nyirenda, M Wilson, MA Mwanyangala, Makandwe Nyirenda, Maria Evandrou, Marie-Louise Newell, MS Westaway, N Ng, N Nguyen, NA Cooperman, P Kowal, P Moen, Paul Kowal, PC Mutevedzi, Portia Mutevedzi, R Benitha, R Ssengonzi, R Ssengonzi, S Dougan, S Hirve, S Jitapunkul, SM Tollman, Somnath Chatterji, SR Kimuna, StataCorp, StataCorp, TA Moultrie, TA Moultrie, United Nations, V Hosegood, V Hosegood, V Hosegood, Victoria Hosegood, W Muhwava, WHO, WHO: ICD-10, WHOQoL Group, Z Zimmer, Z Zimmer   +72 more
core   +2 more sources

Direct Access to α,β‐Unsaturated γ‐Lactams via Palladium‐Catalysed Carbonylation of Propargylic Ureas.

Advanced Synthesis &Catalysis, Volume 367, Issue 5, March 4, 2025.
Abstract Additive carbonylations typically necessitate strong nucleophiles, such as alcohols or amines. In this study, we carbonylated a poorly nucleophilic urea, under oxidant‐free conditions. Our straightforward carbonylative strategy enables access to versatile α,β‐unsaturated γ‐lactams featuring an aminocarbonyl fragment, utilizing readily ...
Debora Schiroli, Aleksandr Voronov, Francesco Pancrazzi, Nunzio Iraci, Salvatore Vincenzo Giofrè, Beatrice Macchi, Valeria Stefanizzi, Raffaella Mancuso, Bartolo Gabriele, Paolo Pio Mazzeo, Luca Capaldo, Nicola Della Ca'   +11 more
wiley   +1 more source

The opioid crisis is driving mortality among under-served people living with HIV in British Columbia, Canada

BMC Public Health, 2021
Introduction Universal provision of effective antiretroviral medication has been essential to reduce mortality, increase longevity, and reduce onward transmission of HIV.
Kate A. Salters, Stephanie Parent, Valerie Nicholson, Lu Wang, Paul Sereda, Tatiana E. Pakhomova, Mia Kibel, William Chau, Kalysha Closson, Surita Parashar, Rolando Barrios, Julio S. G. Montaner, Robert S. Hogg   +12 more
doaj   +1 more source

Docking Studies on HIV Integrase Inhibitors Based On Potential Ligand Binding Sites [PDF]

International Journal on Bioinformatics & Biosciences, vol. 2, pp. 21-29, 2012, 2012
HIV integrase is a 32 kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs. Integrase is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell.
arxiv   +1 more source

Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors

Advanced Therapeutics, EarlyView.
Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe, Jacobus Burger, Jamie Jones, Apurva Panjla, William L. Murphy   +4 more
wiley   +1 more source

Knowledge, attitude and practice towards Coronavirus disease 2019 prevention in Ethiopia: Systematic review and meta-analysis

Journal of Biostatistics and Epidemiology, 2021
Background: Level of knowledge, attitude and practice (KAP) of the community towards corona virus disease 2019 (COVID-19) is important to prevent and control the disease .
Dinka Fikadu Gamtesa, Habteyes Hailu Tola, Gadissa Gutema, Biniyam Dagne, Bira Bejiga Bedassa   +4 more
doaj