Results 71 to 80 of about 2,335,760 (337)

The opioid crisis is driving mortality among under-served people living with HIV in British Columbia, Canada

BMC Public Health, 2021
Introduction Universal provision of effective antiretroviral medication has been essential to reduce mortality, increase longevity, and reduce onward transmission of HIV.
Kate A. Salters, Stephanie Parent, Valerie Nicholson, Lu Wang, Paul Sereda, Tatiana E. Pakhomova, Mia Kibel, William Chau, Kalysha Closson, Surita Parashar, Rolando Barrios, Julio S. G. Montaner, Robert S. Hogg   +12 more
doaj   +1 more source

Reduced Plasma Levels of sCD14 and I-FABP in HIV-infected Patients with Mesalazine-treated Ulcerative Colitis [PDF]

, 2016
BACKGROUND: Microbial translocation (MT) is a shared feature of HIV infection and inflammatory bowel disease (IBD). AIMS: This study was conducted to assess the impact of IBD (and particularly ulcerative colitis, UC) on plasma markers of MT ...
Alessandra Fantauzzi, Caterina Fimiani, Chiara Pasquale, Clementina Maria Galluzzo, Gabriella d’Ettorre, Ivano Mezzaroma, Lucia Palmisano, Manuela Gatto, Manuela Merli, Marina Franco, Massimo Sanchez, Roberta Amici, Silvia Baroncelli, Vincenzo Vullo, Zuleika Michelini   +14 more
core   +1 more source

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy. [PDF]

, 2020
BackgroundIdentifying where human immunodeficiency virus (HIV) persists in people living with HIV and receiving antiretroviral therapy is critical to develop cure strategies.
Anderson, Jenny L, Bacchetti, Peter, Cameron, Paul U, Chomont, Nicolas, Deeks, Steven G, Epling, Christine Lorrie, Fromentin, Rémi, Gartner, Matthew, Hartogensis, Wendy, Hecht, Frederick M, Hoh, Rebecca, Khoury, Gabriela, Lewin, Sharon R, Milush, Jeffrey M, Pitman, Matthew C, Roche, Michael, Sinclair, Elizabeth, Solomon, Ajantha, Somsouk, Ma, Tumpach, Carolin   +19 more
core   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

CD4/CD8 ratio normalization rates and low ratio as prognostic marker for non-AIDS defining events among long-term virologically suppressed people living with HIV

AIDS Research and Therapy, 2018
Background Immune restoration is often incomplete after ART in HIV patients, both quantitatively and qualitatively. We studied the incidence and probability of CD4/CD8 normalization in an adult Thai HIV cohort and explored the predictive value of the ...
Win Min Han, Tanakorn Apornpong, Stephen J. Kerr, Akarin Hiransuthikul, Sivaporn Gatechompol, Tanya Do, Kiat Ruxrungtham, Anchalee Avihingsanon   +7 more
doaj   +1 more source

Diagnostic performance of APRI and FIB-4 for confirming cirrhosis in Indonesian HIV/HCV co-infected patients

BMC Infectious Diseases, 2020
Background After successful of antiretroviral therapy, highly effective direct acting antiviral (DAA) make HCV elimination reasonable in HIV/HCV co-infected patients.
Evy Yunihastuti, Bramantya Wicaksana, Andrian Wiraguna, Ainum Jhariah Hidayah, Fhadilla Amelia, Veritea Natali, Alvina Widhani, Andri Sanityoso Sulaiman, Juferdy Kurniawan   +8 more
doaj   +1 more source

Biphasic Granular Bioinks for Biofabrication of High Cell Density Constructs for Dermal Regeneration

Advanced Healthcare Materials, EarlyView.
This study introduces a biphasic granular bioink (µInk) that enables 3D bioprinting of high cell density constructs for dermal regeneration. The bioink promotes cell proliferation, ECM deposition, and neovascularization, leading to tissue integration and reduced scar formation in vivo.
Rozalin Shamasha, Sneha Kollenchery Ramanathan, Kristin Oskarsdotter, Fatemeh Rasti Boroojeni, Aleksandra Zielińska, Sajjad Naeimipour, Philip Lifwergren, Nina Reustle, Lauren Roberts, Annika Starkenberg, Gunnar Kratz, Peter Apelgren, Karin Säljö, Jonathan Rakar, Lars Kölby, Daniel Aili, Johan Junker   +16 more
wiley   +1 more source

Chemsex, sexualized drug use and emotional vulnerability among men who have sex with men (MSM): a one-month survey in a STI/HIV center

BMC Public Health
Background Chemsex, characterized by the intentional use of specific drugs to enhance sexual experiences during group sessions, represents a challenge for the health of some sexually active communities, such as men who have sex with men (MSM).
Stella Capodieci, Mauro Zaccarelli, Christof Stingone, Eugenia Giuliani, Valentina Cafaro, Laura Gianserra, Maria Gabriella Donà, Alessandra Latini, Massimo Giuliani   +8 more
doaj   +1 more source

Community attitudes on tuberculosis in Botswana: an opportunity for improving the National Tuberculosis Programme outcomes, 2011

BMC Research Notes, 2018
Objectives The Botswana tuberculosis HIV Knowledge Attitude and Practice study sought to assess knowledge, attitudes and practices of communities on TB and identify sources of their information on this disease and HIV.
Godfrey Musuka, Vonai Teveredzi, Lesego Busang, Innocent Chingombe, Panganai Makadzange, Setshwano Mokgweetsinyana, Ronald Ncube, Julita Maradzika, Carmillo Fungai Chinamasa, Themba Moeti   +9 more
doaj   +1 more source