Results 71 to 80 of about 2,248,861 (362)

Efficacy and improvement of lipid profile after switching to rilpivirine in resource limited setting: real life clinical practice

AIDS Research and Therapy, 2019
Background Long-term success of cART is possible if the regimen is convenient and less-toxic. This study assessed the efficacy and safety of switching from a first-line NNRTI or boosted PI-based regimens to RPV-based regimens among virologically ...
Sivaporn Gatechompol, Anchalee Avihingsanon, Tanakorn Apornpong, Win Min Han, Stephen J. Kerr, Kiat Ruxrungtham   +5 more
doaj   +1 more source

HIV and AIDS

DeckerMed Family Medicine, 2021
In the quarter-century since the first report of AIDS in the United States, HIV infection has spread throughout the population, disproportionately affecting black women, Hispanic women, and men who have sex with men. The prognosis for persons infected with HIV has improved dramatically with the introduction and evolution of highly active antiretroviral
openaire   +1 more source

Syphilis serology in HIV-positive and HIV-negative Nigerians: The public health significance [PDF]

, 2006
Syphilis has acquired new potential for morbidity and mortality through association with increased risk for HIV infection. Case-control survey was conducted using Rapid Plasma Reagin test and confirmatory Immunochromatographic test among HIV-positive ...
Alo, Moses, Ariom, Thaddeus, Ogbu, Ogbonnaya, Uneke Jesse, Chigozie   +3 more
core   +1 more source

Enhanced Epithelial Cell Uptake of Glycol Chitosan‐Coated PLGA Nanoparticles for Oral Drug Delivery

Advanced Therapeutics, EarlyView.
Here, glycol chitosan (GC)‐coated PLGA NPs are developed to enhance oral drug delivery by enabling dual‐pathway endocytosis via clathrin‐ and caveolae‐mediated mechanisms. Alginate layering coating on GC‐PLGA further improves oral insulin delivery, achieving sustained glucose reduction in diabetic mice.
Huiwen Pang, Wenxuan Yu, Youzhi Wu, Xuqiang Nie, Guojun Huang, Zhi Ping Xu, Chen Chen, Felicity Y. Han   +7 more
wiley   +1 more source

Anisotropic Surface Microrollers for Endovascular Navigation: A Computational Analysis with a Case Study in Hepatic Perfusion

Advanced Theory and Simulations, EarlyView.
Computational fluid dynamics analyses assess the upstream locomotion performance of anisotropic microrollers with varying height‐to‐width ratios. Observing their successful upstream locomotion in veins, their performance in hepatic circulation is investigated for treating primary liver cancer.
Burak Arslan, Ugur Bozuyuk, Kıvanç Görgülü, Erdost Yildiz, Hakancan Ozturk, Lucia Liotta, Volker Heinemann, Hana Algül, Metin Sitti   +8 more
wiley   +1 more source

Evaluation of HIV counseling and testing in ANC settings and adherence to short course antiretroviral prophylaxis for PMTCT in Francistown, Botswana [PDF]

, 2009
Worldwide, it is estimated that two million children are infected with HIV (USAID 2005). The vast majority of these infections are the result of mother-to-child transmission (MTCT) of the virus during pregnancy, labor, or breastfeeding.
Carolyn Baek, Jennifer Redner, Lee A. Jones, Louis Apicella, Naomi Rutenberg, Tracy Creek   +5 more
core   +1 more source

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. [PDF]

, 2016
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Abdel-Mohsen, Mohamed, Chavez, Leonard, Chew, Glen M, Danesh, Ali, Deeks, Steven G, Deng, Xutao, Hirashima, Mitsuomi, Hoh, Rebecca, Keating, Sheila, Lanteri, Marion, Ndhlovu, Lishomwa C, Niki, Toshiro, Norris, Philip J, Pillai, Satish K, Sacha, Jonah B, Samuels, Michael L, Shikuma, Cecilia M, Tandon, Ravi   +17 more
core   +4 more sources

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

CD4/CD8 ratio normalization rates and low ratio as prognostic marker for non-AIDS defining events among long-term virologically suppressed people living with HIV

AIDS Research and Therapy, 2018
Background Immune restoration is often incomplete after ART in HIV patients, both quantitatively and qualitatively. We studied the incidence and probability of CD4/CD8 normalization in an adult Thai HIV cohort and explored the predictive value of the ...
Win Min Han, Tanakorn Apornpong, Stephen J. Kerr, Akarin Hiransuthikul, Sivaporn Gatechompol, Tanya Do, Kiat Ruxrungtham, Anchalee Avihingsanon   +7 more
doaj   +1 more source

Characterization of the longitudinal HIV-1 quasispecies evolution in HIV-1 infected individuals co-infected with Mycobacterium tuberculosis [PDF]

, 2010
One of the earliest and most striking observations made about HIV is the extensive genetic variation that the virus has within individual hosts, particularly in the hypervariable regions of the env gene which is divided into 5 variable regions (V1-V5 ...
Leulebirhan, Tsigereda Biru
core