Results 71 to 80 of about 696,413 (247)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

Scaling up hepatitis C testing and linkage-to-care among people who use drugs: lessons learned from a pilot project implemented at a supervised consumption site

BMC Health Services Research
Background Despite rolling out publicly-funded hepatitis C virus (HCV) treatment across the province of British Columbia (BC), Canada, 35% of people returning positive HCV RNA results in 2020 did not initiate treatment.
Alannah Hannigan, Nandini Krishnan, Kirti Singh, Shannon Bytelaar, Deb Schmitz, Sofia Bartlett, David Hall, Rolando Barrios, Julio S. G. Montaner, Marianne Harris, Mark W. Hull, Kate A. Salters   +11 more
doaj   +1 more source

HIV leadership programming attendance is associated with PrEP and PEP awareness among young, gay, bisexual, and other men who have sex with men in Vancouver, Canada

BMC Public Health, 2019
Background Young gay, bisexual, and other men who have sex with men (YGBM) may have reduced engagement and knowledge of HIV care and biomedical HIV prevention strategies, such as pre-exposure prophylaxis (PrEP), post-exposure prophylaxis (PEP), and ...
Kalysha Closson, Sarah Chown, Heather L. Armstrong, Lu Wang, Nicanor Bacani, Darren Ho, Jody Jollimore, Gbolahan Olarewaju, David M. Moore, Eric A. Roth, Robert S. Hogg, Nathan J. Lachowsky   +11 more
doaj   +1 more source

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source

Prevalence and incidence of anal high‐grade squamous intraepithelial lesions in a cohort of cisgender men and transgender women who have sex with men diagnosed and treated during acute HIV acquisition in Bangkok, Thailand

Journal of the International AIDS Society
Introduction Men who have sex with men (MSM), especially those living with HIV, are at an increased risk of anal cancer. The prevalence and incidence of its precursor, anal high‐grade squamous intraepithelial lesions (HSILs), among MSM who started ...
Supanat Thitipatarakorn, Nipat Teeratakulpisarn, Siriporn Nonenoy, Aphakan Klinsukontakul, Sujittra Suriwong, Jirat Makphol, Piranun Hongchookiat, Thanyapat Chaya‐ananchot, Napasawan Chinlaertworasiri, Pravit Mingkwanrungruang, Carlo Sacdalan, Kultida Poltavee, Tippawan Pankam, Stephen J. Kerr, Reshmie Ramautarsing, Donn Colby, Nittaya Phanuphak   +16 more
doaj   +1 more source

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Advanced Science, EarlyView.
This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu, Xingyu Zhang, Jingjia Zhang, Gaohui Huang, Chen Zhou, Chunlin Li, Xiaojun Huang, Jianbo Xiao, Nianjie Feng, Yuanbin She   +9 more
wiley   +1 more source

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

PP 3.2 – 00068 Differential transcriptional levels of HIV-1 near full-length and highly deleted proviruses

Journal of Virus Eradication, 2022
T. Nguyen, L. Adams, M.E. Zipparo, A. Glassey, U. Santamaria, C.A. Rehm, J. Earhart, W. Shao, C.Y. Lau, F. Maldarelli   +9 more
doaj   +1 more source

A rational strategy to optimize photodrugs by Molecular Dynamics simulations for killing drug‐resistant Gram‐negative bacteria

AIChE Journal, EarlyView.
Abstract Antimicrobial resistance has become a major threat to human health, particularly for Gram‐negative bacteria such as Acinetobacter baumannii and Klebsiella pneumoniae. Disruption of membrane integrity is regarded as a promising antimicrobial strategy that does not induce distinct drug resistance, while increasing the internalization of drug ...
Lei Hao, Yeonho Song, Cheng Zhang, Yumei Wang, Haoying Ge, Wen Sun, Jingyun Wang, Jun Soo Kim, Xiaojun Peng, Juyoung Yoon, Haidong Li   +10 more
wiley   +1 more source