Results 71 to 80 of about 1,402,138 (245)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Mapping HIV prevalence in sub-Saharan Africa between 2000 and 2017

Nature, 2019
HIV/AIDS is a leading cause of disease burden in sub-Saharan Africa. Existing evidence has demonstrated that there is substantial local variation in the prevalence of HIV; however, subnational variation has not been investigated at a high spatial ...
L. Dwyer-Lindgren, M. Cork, Amber Sligar, Krista M. Steuben, Katherine F Wilson, Naomi R. Provost, B. Mayala, J. Vanderheide, Michael L. Collison, Jason B. Hall, Molly H. Biehl, A. Carter, Tahvi D Frank, Dirk Douwes-Schultz, R. Burstein, Daniel C. Casey, A. Deshpande, Lucas Earl, C. El Bcheraoui, T. Farag, N. Henry, Damaris K. Kinyoki, L. Marczak, M. Nixon, Aaron Osgood-Zimmerman, D. Pigott, R. Reiner, J. Ross, Lauren E. Schaeffer, David L. Smith, Nicole Davis Weaver, K. Wiens, J. Eaton, J. Justman, A. Opio, B. Sartorius, F. Tanser, N. Wabiri, P. Piot, C. Murray, Simon Iain Hay   +40 more
semanticscholar   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

DNA Origami‐Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity

Advanced Materials, EarlyView.
Aptamers displayed on tubular DNA origami nanostructures in defined chiral orientations (left‐ or right‐handed) exhibit enantioselective interactions with cell surface target proteins. While the right‐handed configuration supports only transient binding, the left handedness energetically favors protein dimerization and promotes subsequent ...
Tingjie Song, Abhisek Dwivedy, Dhanush Gandavadi, Gayatri Chandran, Yiquan An, Mengxi Zheng, Xiaojing Wang, Lifeng Zhou, Yang Zhao, Xing Wang   +9 more
wiley   +1 more source

Global Burden of Atherosclerotic Cardiovascular Disease in People Living With HIV: Systematic Review and Meta-Analysis

Circulation, 2018
Background: With advances in antiretroviral therapy, most deaths in people with HIV are now attributable to noncommunicable illnesses, especially cardiovascular disease.
Anoop S. V. Shah, D. Stelzle, K. Lee, E. Beck, S. Alam, S. Clifford, C. Longenecker, F. Strachan, Shashwatee Bagchi, W. Whiteley, S. Rajagopalan, S. Kottilil, H. Nair, D. Newby, D. McAllister, N. Mills   +15 more
semanticscholar   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Community attitudes on tuberculosis in Botswana: an opportunity for improving the National Tuberculosis Programme outcomes, 2011

BMC Research Notes, 2018
Objectives The Botswana tuberculosis HIV Knowledge Attitude and Practice study sought to assess knowledge, attitudes and practices of communities on TB and identify sources of their information on this disease and HIV.
Godfrey Musuka, Vonai Teveredzi, Lesego Busang, Innocent Chingombe, Panganai Makadzange, Setshwano Mokgweetsinyana, Ronald Ncube, Julita Maradzika, Carmillo Fungai Chinamasa, Themba Moeti   +9 more
doaj   +1 more source

Computational Analysis of a GST‐Based Long‐Wave Infrared Microring Resonator on a ZnSe Platform as a Photonic Sensor

Advanced Photonics Research, EarlyView.
A Ge2Sb2Te5 (GST)‐based microring resonator is designed and simulated on a ZnSe‐platform that operates in the long‐wave infrared (LWIR) wavelength of 8 μm. The structure demonstrates strong power confinement and high Q‐factor. GST resonator is used for gas and biosensing applications.
Tanzina Rahman, Md. Islahur Rahman Ebon, Amrita Kumar Sana, Jaker Hossain   +3 more
wiley   +1 more source

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, EarlyView.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source

Identifying HIV infection in South African women: How does a fourth generation HIV rapid test perform?

African Journal of Laboratory Medicine, 2011
Background: HIV rapid tests (RT) play an important role in tackling the HIV pandemic in South Africa. Third generation RT that detect HIV antibodies are currently used to diagnose HIV infection at the point of care.
Kapila Bhowan, Emma Kalk, Sonjiha Khan, Gayle Sherman   +3 more
doaj   +1 more source