Results 91 to 100 of about 1,322,023 (308)

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

Who got vaccinated for mpox? A cross-sectional survey on behavioral correlates of vaccine uptake among men who have sex with men attending an STI/HIV reference center in Rome, Italy

BMC Infectious Diseases
Background Following the 2022 outbreak, vaccination against mpox became available in many European countries using a third-generation non-replicating smallpox vaccine (MVA-BN).
Maria Gabriella Donà, Mauro Zaccarelli, Eugenia Giuliani, Laura Gianserra, Christof Stingone, Francesca Di Tullio, Massimo Giuliani, Alessandra Latini   +7 more
doaj   +1 more source

Management of mental health disorders in HIV-positive patients

Southern African Journal of HIV Medicine, 2013
These guidelines are intended as a reference document to assist HIV nurse and doctor clinicians in managing mental health disorders. It is intended to improve awareness, knowledge and capacity to support patients living with HIV and mental health ...
Southern African HIV Clinicians Society
doaj   +1 more source

HIV stigma fact sheet [PDF]

Let\u2019s Stop HIV Together raises awareness that we all have a role to play in stopping HIV stigma. When we support people with HIV, we make it easier for them to live healthy lives.visit cdc.gov/tobetherPublication date from document properties.cdc ...

core  

The epidemiology of HSV-2 infection and its association with HIV infection in four urban African populations. [PDF]

, 2001
OBJECTIVES: To estimate age- and sex-specific herpes simplex virus type-2 (HSV-2) prevalence in urban African adult populations and to identify factors associated with infection. DESIGN AND METHODS: Cross-sectional, population-based samples of about 2000
Robinson, NJ, Hayes, R. J., Buvé, A, Van Dyck, E, Musonda, R, Zekeng, L, Zekeng, L., Weiss, H. A., Anagonou, S., Robinson, N. J., Morison, L., Laga, M., Caraël, M, Weiss, HA, Anagonou, S, Kahindo, M., Van Dyck, E., Buvé, A., Musonda, R., Study Group on Heterogeneity of HIV Epidemics in African Cities, Caraël, M., Kahindo, M, Morison, L, Laga, M, Hayes, RJ   +24 more
core   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

A Standardized workflow for Orthohantavirus production, detection, and antiviral screening

Virology Journal
Background Orthohantaviruses are zoonotic RNA viruses that cause hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. Their slow replication, lack of cytopathic effects, and variable biosafety requirements have long hindered the
Hannah S. Schwarzer-Sperber, Tamara Mussfeldt, Julia Boesner, Tina Dluzak, Kathrin Sutter, Roland Schwarzer   +5 more
doaj   +1 more source

HIV prevention in the south [PDF]

CDC allocates resources for HIV prevention interventions to populations most affected by HIV.cdc-hiv-prevention-south ...

core  

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source