Results 171 to 180 of about 2,450,636 (325)

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

HIV Antibody [PDF]

, 2020
openaire   +1 more source

Nanoparticles in microdroplets: Recent advances in microfluidic generators for producing functional microbeads

Droplet, EarlyView.
Functional hybrid microbeads with electrical, magnetic, and/or optical responsiveness have emerged as versatile platforms for biotechnology. This review highlights recent advances in microfluidic technologies for producing such microbeads, with a focus on incorporating functional nanoparticles in microdroplet systems.
  Bayinqiaoge, Chengchen Zhang, Shi‐Yang Tang   +2 more
wiley   +1 more source

Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies.

Nature Chemistry, 2016
Sachin S Shivatare, Shih-Huang Chang, Tsung-I Tsai, S. Tseng, Vidya S. Shivatare, Yih‐Shyan Lin, Yang-Yu Cheng, Chien-Tai Ren, C. D. Lee, Sujeet Pawar, Charng-Sheng Tsai, H. Shih, Yi-fang Zeng, Chi-Hui Liang, P. Kwong, D. Burton, Chung-Yi Wu, Chi‐Huey Wong   +17 more
semanticscholar   +1 more source

Blood Transfusions: Are They Life Saving or Transfusing Infections? [PDF]

, 2011
Introduction: There is a risk of 1 - 2 per 1000 recipients receiving contaminated blood with viral, bacterial and parasitic agents.TTI’S are the most commonly encountered complications in transfusion medicine.
Amrutha Kumari, B, Deepa, S, Venkatesha, D   +2 more
core   +1 more source

Brief Report: Seminal Plasma Anti-HIV Antibodies Trigger Antibody-dependent Cellular Cytotoxicity Implications for HIV Transmission

Journal of Acquired Immune Deficiency Syndromes, 2016
M. Parsons, Vijaya Madhavi, Fernanda Ana-Sosa-Batiz, R. Center, K. Wilson, T. Bunupuradah, K. Ruxrungtham, S. Kent   +7 more
semanticscholar   +1 more source

Plant-based production of highly potent anti-HIV antibodies with engineered posttranslational modifications. [PDF]

Sci Rep, 2020
Singh AA, Pooe O, Kwezi L, Lotter-Stark T, Stoychev SH, Alexandra K, Gerber I, Bhiman JN, Vorster J, Pauly M, Zeitlin L, Whaley K, Mach L, Steinkellner H, Morris L, Tsekoa TL, Chikwamba R.   +16 more
europepmc   +1 more source

Nonavalent HPV vaccine to prevent recurrent anal or vulvar high‐grade squamous intraepithelial lesions (VIVA trial): A randomized, double‐blind, placebo‐controlled trial

International Journal of Cancer, EarlyView.
What's New? Anal and vulvar high‐grade squamous intraepithelial lesions (HSILs) frequently recur following treatment. Additional genital and anal procedures, however, can be distressing for patients and are potentially disfiguring. This trial assessed whether the 9‐valent human papillomavirus (9vHPV) vaccine reduces HSIL recurrence risk or HPV ...
Helen C. Stankiewicz Karita, Amalia S. Magaret, David R. Doody, Jeffrey T. Schouten, Constance Mao, Warner K. Huh, Verena S. Grieco, Matthew A. Seymour, Dana Varon, Kelly H. Shrader, Long Fu Xi, Denise A. Galloway, Anna Wald, Margaret M. Madeleine   +13 more
wiley   +1 more source

Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.

Journal of Clinical Investigation, 2015
Jordan R. Willis, G. Sapparapu, S. Murrell, J. Julien, Vidisha Singh, Hannah G King, Yan Xia, Jennifer A. Pickens, C. Labranche, J. Slaughter, D. Montefiori, I. Wilson, J. Meiler, J. Crowe   +13 more
semanticscholar   +1 more source