Results 121 to 130 of about 53,760 (217)

Lenacapavir initiation with concomitant primidone: A case report with therapeutic drug monitoring

British Journal of Clinical Pharmacology, EarlyView.
Lenacapavir (LEN), a first‐in‐class capsid inhibitor, has unique pharmacokinetics that enable twice‐yearly dosing. LEN is not extensively metabolized, although it is a substrate of CYP3A4, which introduces drug–drug interactions concerns. As adoption and implementation of LEN for treatment and prevention increase, additional guidance on concomitant ...
Aaron S. Devanathan, Thomas Glowa, Emily M. Thompson, Amanda J. Saylor, Thomas D. Nolin, Sharon A. Riddler, Ken S. Ho   +6 more
wiley   +1 more source

The CanCURE Survey: Gender-Based Differences in HIV Cure Research Priorities. [PDF]

J Pers Med
Lu J, Vulesevic B, Margolese S, Masching R, Tharao W, Cardinal C, Hedrich T, Mallais C, Dubé K, Cohen E, Chomont N, Costiniuk CT.   +11 more
europepmc   +1 more source

HIV associated immune aging among people living with HIV: implications for long-term antiretroviral therapy and potential HIV cure interventions in sub-Saharan Africa. [PDF]

Front Immunol
Kia P, Kankaka E, Kankundiye P, Tongo M, Nabatanzi R, Mahmoudi T, Nakanjako D.   +6 more
europepmc   +1 more source

The SMAC mimetic AZD5582 reverses HIV latency as a single agent in resting primary CD4+ T cells

Journal of Virus Eradication, 2019
G. Sampey, D. Irlbeck, E. Browne, M. Kanke, E. Cule, S. Wills, S. Falcinelli, Z. Wang, J. Kircherr, B. Allard, E. Stuelke, K. Sholtis, R. Ferris, J. Brehm, D. Favre, J.-P. Routy, C. Jones, N. Archin, D. Margolis, R. Dunham   +19 more
doaj   +1 more source

A British Pharmacological Society Position Statement on Medications in Pregnancy and Lactation

British Journal of Clinical Pharmacology, EarlyView.
Agnesa Mustafa, Cleodie C. Swire, Reya V. Shah, Bernadette Jenner, Rory H. McLean, Muhammad Shamsher Ahmed, Adrie Bekker, Julia Zöllner, Rachel K. Scott, Robert R. Bies, Sara K. Quinney, Dagan O. Lonsdale, Emma Forton Magavern, Catriona Waitt, Anita Banerjee   +14 more
wiley   +1 more source

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte   +3 more
wiley   +1 more source

HIV Cure Research: Ethical and Real-World Practical Considerations for Pediatric and Adolescent Populations. [PDF]

J Pediatric Infect Dis Soc
Ohene-Kyei ET, Salzwedel J, Dubé K, Wada YH, Cotton M, Persaud D, Agwu A.   +6 more
europepmc   +1 more source

Is the Central Nervous System Reservoir a Hurdle for an HIV Cure? [PDF]

Viruses, 2023
Mohammadzadeh N, Chomont N, Estaquier J, Cohen EA, Power C.   +4 more
europepmc   +1 more source

Ferritin as a Nanoparticle Scaffold for Plant‐Produced Next‐Generation Subunit Vaccines

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein nanoparticles offer an innovative approach to next‐generation subunit vaccine development by displaying antigenic sequences on the nanoparticle surface. Compared to traditional subunit vaccines, protein nanoparticle vaccines often show improved interaction with the immune system due to their particulate size and repetitive epitope ...
Jordan T. VanderBurgt, Richard Strasser, Christopher P. Garnham, Rima Menassa   +3 more
wiley   +1 more source

Consensus Building on Strategies That Address Medical Mistrust to Better Engage Priority Populations in HIV Cure Research. [PDF]

Behav Med
Korolkova A, Nguyen E, Ahmed A, Rodriguez Garcia L, Picou B, Dubé K, Sauceda JA.   +6 more
europepmc   +1 more source