Results 271 to 280 of about 156,550 (306)
Some of the next articles are maybe not open access.
BMJ, 2013
Some media reports exaggerated the significance of the recent case of a functional cure of a baby with HIV, but that’s a result of publicising unpublished, non-peer reviewed research, says Margaret ...
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Some media reports exaggerated the significance of the recent case of a functional cure of a baby with HIV, but that’s a result of publicising unpublished, non-peer reviewed research, says Margaret ...
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HIV Cure: Knocking on the Door
Clinical Pharmacology & Therapeutics, 2013Although major advances in drug development and public health are helping to control the HIV/AIDS epidemic, there is a strong rationale for pursuing a more definitive cure. Several bold but unproven strategies for HIV eradication are reviewed in this issue of CPT, including novel drugs, gene therapy, and bone marrow transplantation (BMT). Early results,
C M, Durand, C, Flexner
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Gene therapy to cure HIV infection
Virologie, 2023To date, the only intervention that has cured HIV infection has been bone marrow transplants from HIV-resistant donors to HIV-infected recipients. This approach has been used to both cure hematological malignancies and HIV infection, but it cannot be widely adopted due to the high risk of mortality associated with cell transplants between individuals ...
Ryan P, Goguen +4 more
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HIV reservoirs as obstacles and opportunities for an HIV cure
Nature Immunology, 2015The persistence of HIV reservoirs remains a formidable obstacle to achieving sustained virologic remission in HIV-infected individuals after antiretroviral therapy (ART) is discontinued, even if plasma viremia has been successfully suppressed for prolonged periods of time.
Tae-Wook, Chun +2 more
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2017
Although current antiretroviral therapy (ART) is highly effective at controlling HIV-1 replication, it does not eradicate or cure the infection. HIV-1 persists quiescently in cellular reservoirs, not detected by the immune system due to the lack of active viral replication; these reservoirs represent the major obstacle for cure approaches.
Boris Juelg, Rajesh Gandhi
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Although current antiretroviral therapy (ART) is highly effective at controlling HIV-1 replication, it does not eradicate or cure the infection. HIV-1 persists quiescently in cellular reservoirs, not detected by the immune system due to the lack of active viral replication; these reservoirs represent the major obstacle for cure approaches.
Boris Juelg, Rajesh Gandhi
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Science Translational Medicine, 2013
In an HIV-infected infant who received antiretroviral therapy from 30 hours until 18 months of age, HIV virus was undetectable months after therapy was stopped.
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In an HIV-infected infant who received antiretroviral therapy from 30 hours until 18 months of age, HIV virus was undetectable months after therapy was stopped.
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2019
Upon completion of this chapter, the reader should be able to • Identify key hurdles for HIV eradication strategies and explain how the “Kick and Kill” approaches might overcome these challenges.
Boris Juelg, Rajesh Gandhi
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Upon completion of this chapter, the reader should be able to • Identify key hurdles for HIV eradication strategies and explain how the “Kick and Kill” approaches might overcome these challenges.
Boris Juelg, Rajesh Gandhi
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2014
It may be very difficult to achieve a sterilizing cure for HIV; however, it may be entirely possible to achieve a functional cure for HIV if a large enough number of HIV-resistant hematopoietic stem cells is transplanted into an HIV-infected recipient, eventually creating an immune system that can control the virus.
Gerhard Bauer, Joseph S. Anderson
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It may be very difficult to achieve a sterilizing cure for HIV; however, it may be entirely possible to achieve a functional cure for HIV if a large enough number of HIV-resistant hematopoietic stem cells is transplanted into an HIV-infected recipient, eventually creating an immune system that can control the virus.
Gerhard Bauer, Joseph S. Anderson
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Current Opinion in HIV and AIDS, 2015
Jintanat, Ananworanich, John W, Mellors
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Jintanat, Ananworanich, John W, Mellors
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Ugeskrift for laeger, 2017
The symposium IAS Towards an HIV Cure was held in Melbourne, Australia, in July 2014. There are several challenges regarding an HIV cure, among these the reservoir of latently infected CD4+ T cells which are hidden from the immune system. A new promising approach towards an HIV cure is the "shock and kill" strategy.
Anne Sofie Høgh Kølbæk, Kjær +1 more
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The symposium IAS Towards an HIV Cure was held in Melbourne, Australia, in July 2014. There are several challenges regarding an HIV cure, among these the reservoir of latently infected CD4+ T cells which are hidden from the immune system. A new promising approach towards an HIV cure is the "shock and kill" strategy.
Anne Sofie Høgh Kølbæk, Kjær +1 more
openaire +1 more source