Results 51 to 60 of about 4,520,848 (313)

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

Fluctuations in Blood Marginal Zone B-Cell Frequencies May Reflect Migratory Patterns Associated with HIV-1 Disease Progression Status.

PLoS ONE, 2016
We have previously shown that overexpression of BLyS/BAFF was associated with increased relative frequencies of innate "precursor" marginal zone (MZ)-like B-cells in the blood of HIV-1-infected rapid and classic progressors.
Julie Gauvin, Josiane Chagnon-Choquet, Johanne Poudrier, Michel Roger, Montreal Primary HIV Infection and Slow Progressor Cohorts   +4 more
doaj   +1 more source

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

Nature Medicine, 2018
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption.
D. Colby, L. Trautmann, S. Pinyakorn, L. Leyre, A. Pagliuzza, E. Kroon, M. Rolland, H. Takata, S. Buranapraditkun, J. Intasan, N. Chomchey, Roshell Muir, E. Haddad, S. Tovanabutra, S. Ubolyam, D. Bolton, B. Fullmer, R. Gorelick, L. Fox, T. Crowell, R. Trichavaroj, R. O’Connell, N. Chomont, Jerome H. Kim, N. Michael, M. Robb, N. Phanuphak, J. Ananworanich, P. N. S. M. J. P. P. D. P. S. S. K. N. C. K. R. R. P. Phanuphak Teeratakulpisarn Chottanapund de Souza F, P. Phanuphak, N. Teeratakulpisarn, S. Chottanapund, M. D. de Souza, J. Fletcher, P. Tantivitayakul, P. Eamyoung, D. Sutthichom, P. Prueksakaew, S. Puttamaswin, S. Tipsuk, K. Benjapornpong, N. Ratnaratorn, C. Munkong, K. Tanjnareel, R. Kanaprach, R. Rerknimitr, P. Wattanaboonyongcharoen, P. Rojnuckarin, S. Manasnayakorn, A. Schuetz, S. Akapirat, B. Nuntapinit, N. Tantibul, H. Savadsuk, Y. Phuang-ngern, S. Jongrakthaitae, W. Chuenaron, N. Churikanont, S. Getchalarat, S. Krebs, B. Slike, A. Tokarev, E. Sanders-Buell, M. Bose, C. Ogega, J. Buahen, M. Ouellette, C. McCullough, O. Butterworth, E. Turk, L. A. Eller, M. Milazzo, J. Mitchell, C. Subra, N. Lima, J. Garnett, F. Fatmi, A. Sy, N. Dawson, S Spudich, V. Valcour, F. Maldarelli, I. Sereti, J. Lifson, R. Paul, R. Fromentin, P. Dawson   +86 more
semanticscholar   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment

Frontiers in Immunology, 2021
ObjectiveIn people living with HIV (PLHIV), we sought to test the hypothesis that long term anti-retroviral therapy restores the normal T cell repertoire, and investigate the functional relationship of residual repertoire abnormalities to persistent ...
Carolin T. Turner, James Brown, James Brown, Emily Shaw, Imran Uddin, Evdokia Tsaliki, Jennifer K. Roe, Gabriele Pollara, Yuxin Sun, James M. Heather, Marc Lipman, Marc Lipman, Benny Chain, Mahdad Noursadeghi   +13 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

The Human Penis Is a Genuine Immunological Effector Site

Frontiers in Immunology, 2017
The human penis is a main portal of entry for numerous pathogens, and vaccines able to control resulting infections locally are highly desirable. However, in contrast to the gastrointestinal or vaginal mucosa, the penile immune system and mechanisms ...
Alexis Sennepin, Alexis Sennepin, Alexis Sennepin, Fernando Real, Fernando Real, Fernando Real, Marine Duvivier, Marine Duvivier, Marine Duvivier, Yonatan Ganor, Yonatan Ganor, Yonatan Ganor, Sonia Henry, Sonia Henry, Sonia Henry, Diane Damotte, Marc Revol, Sonia Cristofari, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +20 more
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Use and awareness of and willingness to self-test for HIV: an analysis of cross-sectional population-based surveys in Malawi and Zimbabwe

BMC Public Health, 2020
Background Many southern African countries are nearing the global goal of diagnosing 90% of people with HIV by 2020. In 2016, 84 and 86% of people with HIV knew their status in Malawi and Zimbabwe, respectively.
Cheryl Johnson, Melissa Neuman, Peter MacPherson, Augustine Choko, Caitlin Quinn, Vincent J. Wong, Karin Hatzold, Rose Nyrienda, Getrude Ncube, Rachel Baggaley, Fern Terris-Prestholt, Elizabeth L. Corbett   +11 more
doaj   +1 more source