Results 101 to 110 of about 1,835,308 (309)

High rate of loss to clinical follow up among African HIV‐infected patients attending a London clinic: a retrospective analysis of a clinical cohort

Journal of the International AIDS Society, 2010
Background Long‐term regular clinic follow up is an important component of HIV care. We determined the frequency and characteristics of HIV‐infected patients lost to follow up from a London HIV clinic, and factors associated with loss to all HIV follow ...
Sarah M Gerver, Tim R Chadborn, Fowzia Ibrahim, Bela Vatsa, Valerie C Delpech, Philippa J Easterbrook   +5 more
doaj   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Geographical variations in the prevalence of HIV and other sexually transmitted infections in rural Tanzania.

, 2003
The prevalence and incidence of HIV and other sexually transmitted infections (STIs) were recorded in two lake-island and eight rural mainland communities in Mwanza, Tanzania.
Obasi, A, Changalucha, John, Mabey, David, Morison, Linda, Mosha, Frank, Rusizoka, M, Changalucha, J, Mayaud, P, Mayaud, Philippe, Obasi, Angela, Todd, James, Munguti, K, Jansen, Henrica AFM, Jansen, HAFM, Grosskurth, H, Mabey, D, Munguti, Katua, Rusizoka, Mary, Mosha, F, Hayes, Richard, Morison, L, Grosskurth, Heiner, Todd, J, Hayes, R   +23 more
core   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Comprehensive care lowers multimorbidity, impairment, disability and absenteeism in people with TB

IJTLD Open
SUMMARY: A substantial proportion of TB survivors experience poor health, live with comorbidities or experience impairments or disability, even when TB is successfully treated.
F. Mavhunga, K. Viney, A. Baddeley, C.M. Halleux, G. Aslanyan   +4 more
doaj   +1 more source

HIV-Infected Patients

Biology of Blood and Marrow Transplantation, 2009
High-dose chemotherapy and autologous stem cell transplantation (SCT) or allogeneic SCT can lead to durable remissions in patients with hematologic malignancies. In the mid-1980s the first studies demonstrating the use of peripheral blood stem cells (PBSC) for autologous transplantation instead of bone marrow (BM) were performed.
openaire   +2 more sources

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

The Virgin HIV Puzzle: Can misreporting account for the high proportion of HIV cases in self-reported virgins? [PDF]

The Demographic and Health Surveys from Lesotho, Zimbabwe, and Malawi reveal that a significant proportion of HIV infections in adolescent women occurred in women who claim to be virgin.
Deuchert, Eva
core  

The epidemiology of HIV and HSV-2 infections among women participating in microbicide and vaccine feasibility studies in Northern Tanzania. [PDF]

, 2013
OBJECTIVES: To prepare for future HIV prevention trials, we conducted prospective cohort studies among women working in food and recreational facilities in northern Tanzania.
Watson-Jones Deborah, Joseph Chilongani, Mongi Aika, Watson-Jones, Deborah, John Changalucha (243873), Hashim, Ramadhan, Tony Ao (434475), Hayes Richard, Saidi H. Kapiga (124370), Saidi H Kapiga, Aika Mongi, Aura Andreasen, Deborah Watson-Jones, Aika Mongi (434477), Kathy Baisley (132119), Ramadhan Hashim (148699), Deborah Watson-Jones (230055), Chilongani Joseph, Baisley, Kathy, Francis, Suzanna, Changalucha John, Fiona M. Ewings (309182), Hayes, Richard, Richard Hayes, Chilongani, Joseph, Kathy Baisley, Suzanna Francis, Richard Hayes (32740), Changalucha, John, Aura Andreasen (247728), Joseph Chilongani (434476), Kapiga, Saidi H, Ao, Tony, Mongi, Aika, Andreasen, Aura, Ramadhan Hashim, Andreasen Aura, John Changalucha, Hashim Ramadhan, Francis Suzanna, Ao Tony, Tony Ao, Baisley Kathy, Fiona M Ewings, Ewings Fiona M., Suzanna Francis (434478), Kapiga Saidi H., Ewings, Fiona M   +47 more
core   +1 more source