Results 101 to 110 of about 1,751,474 (312)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

The Association between Female Genital Cutting and Spousal HCV Infection in Egypt

International Journal of Hepatology, 2014
Objective. To identify the risk factors for HCV infection within married couples in Egypt. Methods. In 2008 Egypt conducted its first nationally representative survey of HCV prevalence.
Chris R. Kenyon, Robert Colebunders
doaj   +1 more source

Do employees participate in workplace HIV testing just to win a lottery prize? A quantitative study

SA Journal of Human Resource Management, 2016
Orientation: To encourage workers to participate in workplace HIV testing, some SouthAfrican automotive companies use lotteries. However, there is a lack of empirical evidence on how lottery incentives may influence employees’ workplace HIV counselling ...
Martin Weihs, Anna Meyer-Weitz
doaj   +1 more source

Advancing HIV Prevention progress summary April 2003-September 2005 [PDF]

On April 17, 2003, the Centers for Disease Control and Prevention (CDC) announced a new initiative, \u201cAdvancing HIV Prevention (AHP): New Strategies for a Changing Epidemic.\u201d Its aim is to reduce barriers to early diagnosis of HIV infection and ...

core  

Discontinuation of secondary prophylaxis against Pneumocystis carinii pneumonia in patients with HIV infection who have a response to antiretroviral therapy [PDF]

, 2001
Background: Patients with human immunodeficiency virus (HIV) infection and a history of Pneumocystis carinii pneumonia are at high risk for relapse if they are not given secondary prophylaxis. Whether secondary prophylaxis against P.
H. Furrer, Uberti-Foppa, C., Pradier, C., Bickel, M, Monforte, A D´Arminio, Bickel, M., M. M. E. Schneider, Uberti-Foppa, C, O. Kirk, Furrer, H, Kirk, O., Schneider, M. M., Kirk, O, Lundgren, Jens Dilling, Ledergerber, B., Mocroft, A., Ledergerber, B, Lundgren, J.D., M. Bickel, P. Reiss, Lundgren, J. D., d'Arminio Monforte, A., Pradier, C, A. d'Arminio Monforte, Lederberger, B., Furrer, H., Reiss, P, Schneider, MM, A. Mocroft, for eight European HIV Cohorts, B. Ledergerber, C. Pradier, J. D. Lundgren, Schneider, M.M.E., Mocroft, A, Reiss, P., C. Uberti Foppa   +36 more
core   +2 more sources

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Usefulness of Dried Blood Spot Samples for Syphilis Screening

LabMed
Dried blood spots (DBSs) are a practical tool for diagnosing infectious diseases, especially in remote or resource-limited settings. This study assessed the efficacy of DBS-based serological assays for syphilis screening.
Victoria González Soler, Gema Fernández-Rivas, Héctor Martínez Riveros, Pablo Pillado Alonso, Yesika Díaz Rodríguez, Marcos Montoro Fernández, Miquel Saña Miralles, Pere Joan Cardona Iglesias, Jordi Casabona Barbarà, C. Agusti   +9 more
doaj   +1 more source

Stigma and Dissatisfaction of Health Care Personnel in HIV Response in Iran: A Qualitative Study

Journal of the International Association of Providers of AIDS Care, 2019
Background and Aims: With regard to the disease pandemics of HIV/AIDS, it is clear that there is need for prevention, treatment, care, and support of HIV positive patients in the health care system.
Mehrnaz Rasoolinejad MD, Nasrin Abedinia PhD, Ahmad Ali Noorbala MD, Minoo Mohraz MD, Ian McMillan BSc, Banafsheh Moradmand MD, John Henry Gilkison MSc   +6 more
doaj   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source