Results 81 to 90 of about 1,751,474 (312)

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Risk factors for herpes simplex virus type 2 and HIV among women at high risk in northwestern Tanzania: preparing for an HSV-2 intervention trial. [PDF]

, 2007
OBJECTIVES: To determine prevalence of and risk factors for herpes simplex virus type 2 (HSV-2) and HIV among women being screened for a randomized, controlled trial of HSV suppressive therapy in northwestern Tanzania. METHODS: Two thousand seven hundred
Mugeye, Kokugonza, Hayes, Richard J, Balira, Rebecca, Knight, Louise, Ross, David, Changalucha, John, Weiss, Helen A, Baisley, Kathy, Watson-Jones, Deborah, Rusizoka, Mary, Everett, Dean   +10 more
core   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

Health challenges in South African automotive companies: Wellness in the workplace

SA Journal of Human Resource Management, 2015
Orientation: In South Africa, workplace programmes in the automotive industry focus predominantly on occupational health and safety and HIV and AIDS. The implementation of focused workplace interventions might be hampered when companies are not convinced
Anna Meyer-Weitz, Friederike Baasner-Weihs, Martin Weihs   +2 more
doaj   +1 more source

The potential impact of male circumcision on HIV in Sub-Saharan Africa. [PDF]

, 2006
\ud A randomized controlled trial (RCT) has shown that male circumcision (MC) reduces sexual transmission of HIV from women to men by 60% (32%-76%; 95% CI) offering an intervention of proven efficacy for reducing the sexual spread of HIV.
Getz, Wayne M., Auvert, Bertran, Brian G Williams, Catherine Hankins, Bertran Auvert, Lloyd-Smith, James, O., Hankins Catherine, Hargrove John, Lloyd-Smith, James O, Lloyd-Smith, James,, Wayne M Getz, Getz, Wayne, M., Isabelle de Zoysa, Christopher Dye, Lloyd-Smith, James O., Auvert Bertran, de Zoysa, Isabelle, John Hargrove, Williams, Brian,, Williams, Brian G., Getz, Wayne M, James O Lloyd-Smith, Eleanor Gouws, Dye, Christopher, Williams, Brian, G., Dye Christopher, James O. Lloyd-smith, Williams Brian G, Williams, Brian G, Hankins, Catherine, Brian G. Williams, Lloyd-Smith James O, Gouws Eleanor, de Zoysa Isabelle, Hargrove, John, Getz, Wayne,, Gouws, Eleanor, Getz Wayne M   +37 more
core   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Tuberculosis at the crossroads: urgent actions for migrant and refugee health in a turbulent era

BMJ Global Health
Tuberculosis (TB) remains the world’s deadliest infectious disease kiler, affecting the most vulnerable, including refugees and migrants. Their vulnerability is intensified by structural and social barriers that hinder diagnosis and treatment and ...
Kerri Viney, Tereza Kasaeva, Allen Gidraf Kahindo Maina, Hannah Monica Dias, Farai Mavhunga, Martin van den Boom, Santino Severoni, Josette Najjar-Pellet, Diana Abou Ismail, Sanaa T Al-Harahsheh, Poonam Dhavan   +10 more
doaj   +1 more source

STI in times of PrEP: high prevalence of chlamydia, gonorrhea, and mycoplasma at different anatomic sites in men who have sex with men in Germany

BMC Infectious Diseases, 2020
Background Men who have sex with men (MSM) are disproportionally affected by sexually transmitted infections (STI). STI are often extragenital and asymptomatic. Both can delay diagnosis and treatment. Approval of HIV pre-exposure prophylaxis (PrEP) might
Klaus Jansen, Gyde Steffen, Anja Potthoff, Ann-Kathrin Schuppe, Daniel Beer, Heiko Jessen, Stefan Scholten, Petra Spornraft-Ragaller, Viviane Bremer, Carsten Tiemann, MSM Screening Study group   +10 more
doaj   +1 more source

HIV and injection drug use [PDF]

Fast facts:\ue2\u20ac\ua2 HIV infections due to injection drug use have declined, but injecting drugs remains a significant risk.\ue2\u20ac\ua2 Sharing syringes is a direct route of HIV transmission.\ue2\u20ac\ua2 In one study, two out of five people who

core  

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source