Results 41 to 50 of about 788,644 (353)

Immune compromise in HIV-1/HTLV-1 coinfection with paradoxical resolution of CD4 lymphocytosis during antiretroviral therapy: a case report [PDF]

, 2015
Human immunodeficiency virus type-1 (HIV-1) and human T lymphotropic virus type-1 (HTLV-1) infections have complex effects on adaptive immunity, with specific tropism for, but contrasting effects on, CD4 T lymphocytes: depletion with HIV-1, proliferation
Bangham, C, Basnayake, S, Cook, L, Kagdi, H, Pozniak, A, Rockwood, N, Taylor, GP   +6 more
core   +2 more sources

What do primary care staff know and do about blood borne virus testing and care for migrant patients? A national survey

BMC Public Health, 2021
Background UK migrants born in intermediate to high prevalence areas for blood borne viruses (BBV) including hepatitis B, hepatitis C and HIV are at increased risk of these infections.
Rachel Roche, Ruth Simmons, Alison F. Crawshaw, Pip Fisher, Manish Pareek, Will Morton, Theresa Shryane, Kristina Poole, Arpana Verma, Ines Campos-Matos, Sema Mandal   +10 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Strong associations between national prevalence of various STIs suggests sexual network connectivity is a common underpinning risk factor

BMC Infectious Diseases, 2017
Background If national peak Human Immunodeficiency Virus (HIV) prevalence is positively associated with the prevalence of other sexually transmitted infections (STIs) from before or early on in the HIV epidemics this would suggest common underlying ...
Chris Kenyon
doaj   +1 more source

Black Americans and HIV/AIDS [PDF]

, 2013
Black Americans have been disproportionately affected by HIV/AIDS since the epidemic's beginning, and that disparity has deepened over time. Blacks account for more new HIV infections, people estimated to be living with HIV disease, and HIV-related ...

core  

Is the HCV-HIV co-infection prevalence amongst injecting drug users a marker for the level of sexual and injection related HIV transmission?

, 2013
BACKGROUND: Amongst injecting drug users (IDUs), HIV is transmitted sexually and parenterally, but HCV is transmitted primarily parenterally. We assess and model the antibody prevalence of HCV amongst HIV-infected IDUs (denoted as HCV-HIV co-infection ...
Beattie, Tara, EMCDDA Collaborative Group, Hickman, Matthew, Jarlais, Don Des, Martin, Natasha K, Roy, Anuradha, Strathdee, Steffanie, Vickerman, Peter, Wiessing, Lucas   +8 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Rush to Judgment: The STI-Treatment Trials and HIV in Sub-Saharan Africa

, 2015
Introduction: The extraordinarily high incidence of HIV in sub-Saharan Africa led to the search for cofactor infections that could explain the high rates of transmission in the region.
Akobeng, Anzala, Auvert, Boily, Cartwright, Celum, Celum, Cohen, Deaton, Downs, Eileen Stillwaggon, Estellat, Feldmeier, Fleming, Ghys, Ghys, Ghys, Glynn, Grabowski, Gray, Gray, Gregson, Grosskurth, Grosskurth, Habicht, Harms, Hayes, Hayes, Hayes, Hotez, Hugonnet, Kamali, Kaul, Kaul, Kinzig, Kjetland, Kjetland, Korenromp, Larry Sawers, Larson, Leutscher, Looker, Martin, Modjarrad, Ng, Orroth, Orroth, Orroth, Padian, Pickering, Poggensee, Poggensee, Quigley, R ttingen, Rotchford, Rothman, Rothman, Rothman, Sangani, Schwartz, Schwebke, Sewankambo, Sexton, Stillwaggon, Stillwaggon, Taha, Todd, Victora, Watson-Jones, Watson-Jones, Wawer, WHO, Department of Measurement and Health Information, Wijgert, Wijgert, Wolday, World Health Organization, Worrall   +76 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source