Results 71 to 80 of about 484,489 (312)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Active and resolved HCV infections among people with new HIV-1 diagnoses in Germany, 2009–2019

BMC Infectious Diseases
Background HIV and HCV share similar routes of infection. Individuals carrying both viruses experience a faster progression of the liver disease. We have analyzed people with new HIV-1 diagnoses in Germany for active or resolved HCV infection for over ...
Daniel Ivanusic, Amare Eshetu, Hussein Al-Shehabi, Andrea Hauser, Patrycja Klink, Daniel Schmidt, Uwe Koppe, Barbara Gunsenheimer-Bartmeyer, Viviane Bremer, Norbert Bannert   +9 more
doaj   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Health challenges in South African automotive companies: Wellness in the workplace

SA Journal of Human Resource Management, 2015
Orientation: In South Africa, workplace programmes in the automotive industry focus predominantly on occupational health and safety and HIV and AIDS. The implementation of focused workplace interventions might be hampered when companies are not convinced
Anna Meyer-Weitz, Friederike Baasner-Weihs, Martin Weihs   +2 more
doaj   +1 more source

STI in times of PrEP: high prevalence of chlamydia, gonorrhea, and mycoplasma at different anatomic sites in men who have sex with men in Germany

BMC Infectious Diseases, 2020
Background Men who have sex with men (MSM) are disproportionally affected by sexually transmitted infections (STI). STI are often extragenital and asymptomatic. Both can delay diagnosis and treatment. Approval of HIV pre-exposure prophylaxis (PrEP) might
Klaus Jansen, Gyde Steffen, Anja Potthoff, Ann-Kathrin Schuppe, Daniel Beer, Heiko Jessen, Stefan Scholten, Petra Spornraft-Ragaller, Viviane Bremer, Carsten Tiemann, MSM Screening Study group   +10 more
doaj   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

HIV ANTIGENAEMIA IN ACUTE HIV INFECTION

The Lancet, 1987
-Human immunodeficiency virus (HIV) infection maypresent as an acute illness, probably occurring shortly after virusacquisition.1.2 Most cases have been diagnosed retrospectivelyfollowing seroconversion. We have seen two patients with a clinicalpicture compatible with acute HIV disease, and have tested theiracute phase sera for HIV antigen.
Wall, R A, Denning, D W, Amos, A
openaire   +1 more source

Membrane Vesicles from Lacticaseibacillus Casei BL23 Exhibit Antimicrobial Activity Against Escherichia coli and Immunostimulatory Effects on Human Peripheral Blood Mononuclear Cells

Advanced Healthcare Materials, EarlyView.
Membrane vesicles derived from the probiotic Lacticaseibacillus casei BL23 demonstrate antimicrobial properties against Escherichia coli and a potential biological effect in improving the overall survival of C. elegans infected with Pseudomonas aeruginosa. These vesicles stimulated immune responses in primary cells without causing toxicity. Our results
Cecilia L. D'Antoni, Leila Pourtalebi Jahromi, Lorenzo Sana, Ana Paula Domínguez Rubio, Maja Dorfner, Jennifer Munkert, Heike Danzer, Philipp Arnold, Mikhail Lebedev, Esther Zanin, Oscar E. Pérez, Gregor Fuhrmann   +11 more
wiley   +1 more source

Tuberculosis at the crossroads: urgent actions for migrant and refugee health in a turbulent era

BMJ Global Health
Tuberculosis (TB) remains the world’s deadliest infectious disease kiler, affecting the most vulnerable, including refugees and migrants. Their vulnerability is intensified by structural and social barriers that hinder diagnosis and treatment and ...
Kerri Viney, Tereza Kasaeva, Allen Gidraf Kahindo Maina, Hannah Monica Dias, Farai Mavhunga, Martin van den Boom, Santino Severoni, Josette Najjar-Pellet, Diana Abou Ismail, Sanaa T Al-Harahsheh, Poonam Dhavan   +10 more
doaj   +1 more source

High rate of loss to clinical follow up among African HIV‐infected patients attending a London clinic: a retrospective analysis of a clinical cohort

Journal of the International AIDS Society, 2010
Background Long‐term regular clinic follow up is an important component of HIV care. We determined the frequency and characteristics of HIV‐infected patients lost to follow up from a London HIV clinic, and factors associated with loss to all HIV follow ...
Sarah M Gerver, Tim R Chadborn, Fowzia Ibrahim, Bela Vatsa, Valerie C Delpech, Philippa J Easterbrook   +5 more
doaj   +1 more source