Results 11 to 20 of about 26,857 (227)
Pharmacology of HIV integrase inhibitors [PDF]
Current Opinion in HIV and AIDS, 2012 The purpose of this paper is to review recent and relevant pharmacology data for three HIV integrase inhibitors: raltegravir (marketed), dolutegravir and elvitegravir (both in Phase III drug development).
Jessica L, Adams +2 more
openaire +4 more sources
HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin [PDF]
Retrovirology, 2011 Background Chromatin binding plays a central role in the molecular mechanism of LEDGF/p75 in HIV-1 DNA integration. Conflicting results have been reported in regards to the relevance of the LEDGF/p75 chromatin binding element PWWP domain in its HIV-1 ...
Garcia-Rivera Jose A +5 more
doaj +2 more sources
Novel therapeutic strategies targeting HIV integrase
BMC Medicine, 2012 Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an ...
Quashie Peter K +2 more
doaj +2 more sources
Integrase variability and susceptibility to HIV integrase inhibitors: impact of subtypes, antiretroviral experience and duration of HIV infection [PDF]
Journal of Antimicrobial Chemotherapy, 2009 Little is known about the extent and predictors of polymorphisms potentially influencing the susceptibility to HIV integrase inhibitors (INIs).Genetic sequences of HIV integrase were obtained from INI-naive patients at two European clinics. The 39 amino acid changes at 29 integrase positions so far associated with INI resistance were examined according
Garrido, C. +6 more
openaire +4 more sources
mBio, 2017 Resistance to the integrase strand transfer inhibitors raltegravir and elvitegravir is often due to well-identified mutations in the integrase gene. However, the situation is less clear for patients who fail dolutegravir treatment.
Isabelle Malet +7 more
doaj +2 more sources
HIV-1 Integrase and ALLINI Structure.
, 2023 A. Domain Map of HIV-1 Integrase. B. The preclinical lead ALLINI BI-224436. Chemical features common to the ALLINI class are highlighted, including a carboxylic acid moiety (salmon), a tert-butoxy moiety (green), and a large hydrophobic appendage at the ...
Audrey Allen (9324850) +8 more
core +1 more source
Emerging patterns in HIV integrase resistance. [PDF]
AIDSWe assessed integrase resistance in 837 treatment-experienced people with HIV (PWH) with virological failure (2022–2024) in Portugal. Major resistance mutations were found in 5.5%, with N155H and R263K being the most common. Resistance was more frequent in non-B subtypes and often co-occurred with resistance to other antiretroviral classes.
Veloso M +10 more
europepmc +3 more sources
Integrase and integration: biochemical activities of HIV-1 integrase [PDF]
Retrovirology, 2008 Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses integration. The process of integration can be divided into two sequential reactions.
Deprez Eric +4 more
openaire +3 more sources
Treatment of HIV Infections with HIV Integrase Inhibitors. [PDF]
ACS Med Chem Lett, 2017 Abdel-Magid AF.
europepmc +4 more sources
Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]
, 2013 HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core +1 more source