Results 31 to 40 of about 26,857 (227)

Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function

mBio, 2020
Integration of the proviral DNA intermediate into the host cell genome normally represents an essential step in the retroviral life cycle. While the reason(s) for this requirement remains unclear, it is known that unintegrated proviral DNA is ...
Ishak D. Irwan, Heather L. Karnowski, Hal P. Bogerd, Kevin Tsai, Bryan R. Cullen   +4 more
doaj   +1 more source

GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration

Scientific Reports, 2017
GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection.
A. Jaspart, C. Calmels, O. Cosnefroy, P. Bellecave, P. Pinson, S. Claverol, V. Guyonnet-Dupérat, B. Dartigues, M. S. Benleulmi, E. Mauro, P. A. Gretteau, V. Parissi, M. Métifiot, M. L. Andreola   +13 more
doaj   +1 more source

Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors

European Journal of Medicinal Chemistry Reports
Acquired immune deficiency syndrome (AIDS) diseases despite the efficacy of anti-HIV therapy, remain one of the human's most serious problems. Hence, the introduction of novel anti-HIV agents as first-line therapy is still required. HIV integrase lacking
Nafiseh Karimi, Amirreza Dowlati Beirami, Rouhollah Vahabpour Roudsari, Zahra Hajimahdi, Afshin Zarghi   +4 more
doaj   +1 more source

Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication

Virology Journal, 2019
Background HIV-1 hijacks the cellular machinery for its own replication through protein-protein interactions between viral and host cell factors. One strategy against HIV-1 infection is thus to target these key protein complexes.
Fadila Larguet, Clément Caté, Benoit Barbeau, Eric Rassart, Elsy Edouard   +4 more
doaj   +1 more source

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV. [PDF]

PLoS Pathogens, 2007
Retroviruses by definition insert their viral genome into the host cell chromosome. Although the key player of retroviral integration is viral integrase, a role for cellular cofactors has been proposed.
Anneleen Hombrouck, Jan De Rijck, Jelle Hendrix, Linos Vandekerckhove, Arnout Voet, Marc De Maeyer, Myriam Witvrouw, Yves Engelborghs, Frauke Christ, Rik Gijsbers, Zeger Debyser   +10 more
doaj   +1 more source

Integrase Inhibitor Prodrugs: Approaches to Enhancing the Anti-HIV Activity of β-Diketo Acids

Molecules, 2015
HIV integrase, encoded at the 3′-end of the HIV pol gene, is essential for HIV replication. This enzyme catalyzes the incorporation of HIV DNA into human DNA, which represents the point of “no-return” in HIV infection.
Vasu Nair, Maurice Okello
doaj   +1 more source

Patterns of resistance development with integrase inhibitors in HIV

, 2011
Jean L Mbisa, Supang A Martin, Patricia A CaneVirus Reference Department, Microbiology Services, Health Protection Agency, London, UKAbstract: Raltegravir, the only integrase (IN) inhibitor approved for use in HIV therapy, has recently been licensed ...
Patricia A Cane, null Mbisa, Jean L Mbisa, null Martin, Supang A Martin, Pat Cane   +5 more
core   +1 more source

No difference in HIV-1 integrase resistance between CSF and blood compartments Short title: HIV-1 integrase resistance in compartments

, 2021
International audienceBackground: Little is known about the HIV-1 integrase resistance in CNS. This study aimed to evaluate integrase resistance in CSF, as a marker of CNS, and compare it to the HIV resistance in plasma.
Simon, Anne, Palich, Romain, Teyssou, Elisa, Abdi, Basma, Katlama, Christine, Marcelin, Anne-Geneviève, Calvez, Vincent, Seang, Sophie, Chebbi, Mouna, Tubiana, Roland, Soulié, Cathia, Wirden, Marc, Valantin, Marc-Antoine, Sayon, Sophie   +13 more
core   +1 more source

CoMFA and CoMSIA Studies on Inhibitors of HIV-1 Integrase - Bicyclic Pyrimidinones

E-Journal of Chemistry, 2010
To understand the structural requirements of HIV-1 integrase inhibitors and to design new ligands against human HIV-1 integrase with enhanced inhibitory potency, a 3D QSAR (quantitative structure-activity relationship) study with comparative molecular ...
V. Radhika, S. Sree Kanth, M. Vijjulatha
doaj   +1 more source

HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana

Viruses, 2021
There are limited real-world mutational and virological outcomes data of treatment-experienced persons diagnosed with HIV-1 subtype C (HIV-1 C) who are failing Integrase Strand Transfer Inhibitor-based regimens. Requisition forms sent for HIV-1 genotypic
Kaelo K. Seatla, Dorcas Maruapula, Wonderful T. Choga, Tshenolo Ntsipe, Nametso Mathiba, Mompati Mogwele, Max Kapanda, Bornapate Nkomo, Dinah Ramaabya, Joseph Makhema, Mompati Mmalane, Madisa Mine, Ishmael Kasvosve, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe   +15 more
doaj   +1 more source